Investigating the genetic bases of age-related hearing loss - human GWAS to mouse modelsAguilar, C.Newton, S.Flook, M.Brown, S. D. M.Dawson, S. J.Bowl, M. R.Journal of Hearing Science
Here, we review the histopathological changes underlying age-related and noise-induced hearing loss and the functional consequences of these pathologies. Based on these relations, we consider the ambiguities that arise in diagnosing underlying pathology from minimally invasive tests of auditory function, ...
Age-related hearing loss (presbycusis) is a common human disorder, affecting one in three Americans aged 60 and over. Previous studies have shown that presbyacusis is associated with a loss of non-sensory cells in the cochlear lateral wall. Sox10 is a transcription factor crucial to the devel...
Sensorineural hearing loss affects the quality of life and communication of millions of people, but the underlying molecular mechanisms remain elusive. Here, we identify mutations inGipc3underlying progressive sensorineural hearing loss (age-related hearing loss 5,ahl5) and audiogenic seizures (juvenile...
Age-related hearing impairment (ARHI) is very common in older adults and has major impact on quality of life. The heritability of ARHI has been estimated to be around 50%. The present study aimed to estimate heritability and environmental contributions to liability of ARHI and the extent to wh...
The Changes of SOD,MDA and Apoptosis in the Auditory Cortex,the Cochlear Nuclei and the Cochlea of the Rats with Age-Related Hearing Loss the rats with age-related hearing loss were important in the development of presbyacusis,and oxidative damage might be one of the mechanisms of apoptosis....
Age-related hearing loss affects a large and growing segment of the population, with profound impacts on quality of life. Age-related pathology of the coch... K Castano-Gonzalez,C Koeppl,SJ Pyott - 《Hearing Research An International Journal》 被引量: 0发表: 2024年 NON-HUMAN ANIMAL MODELS...
Race and sex differences in age-related hearing loss: The health, aging and body composition study Journal of the American Geriatrics Society, 53 (12) (2005), pp. 2119-2127 CrossrefView in ScopusGoogle Scholar Houx and Jolles, 1993 P.J. Houx, J. Jolles Age-related decline of psychomotor...
et al. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell 143, 802–812, doi: 10.1016/j.cell.2010.10.002 (2010). 20. Paulin, R. et al. Sirtuin 3 Deficiency Is Associated with Inhibited Mitochondrial Function and Pulmonary ...
Y. A major gene affecting age-related hearing loss in C57BL/6J mice. Hear. Res. 114, 83–92 (1997). CAS PubMed Google Scholar Doran, A. G. et al. Deep genome sequencing and variation analysis of 13 inbred mouse strains defines candidate phenotypic alleles, private variation and ...