The ability of HTSU-IgG to bind to T cells that are still naive, as judged by their CD45RAhigh, CD45RO−phenotype, suggests that the HTLV-I SU binding protein is an early marker for T-cell activation and that activated naive T cells can be targets for HTLV-I infection. Download: ...
HTLV-1 utilizes CD4 T cells as the main host cell and maintains the proviral load via clonal proliferation of infected CD4+ T cells. Infection of CD4+ T cells by HTLV-1 is therefore thought to play a pivotal role in HTLV-1-related pathogenicity, includin
antibody (Mab) which, as noted above, is has the same specificity as antibodies present in patients with T-cell leukemia related to HTLV-I infection. The antibody is produced by the EBV-transformed B-lymphocyte cell line having ATCC Deposit No. HB8755 (New ATCC NO. HB10571) (See ...
that causes this disease. We discuss HTLV-1 infectivity and how the HTLV-1 Tax oncoprotein initiates transformation by creating a cellular environment favouring aneuploidy and clastogenic DNA damage. We also explore the contribution of a newly discovered protein and RNA on the HTLV-1 minus strand,...
HTLV-1 has co-existed with humans for the past 20,000–30,000 years43. The virus may have evolved this strategy—the presence of an internal insulator and enhancer region in the provirus—to achieve persistent infection under pressure from the host system to silence foreign DNA elements as ...
infection are thought to be associated with differences in the host response to the virus rather than the virus itself. Several lifetime risks of developing HAM/TSP have been reported including human leukocyte antigen (HLA) and non-HLA gene polymorphisms. The HLA class I genotype of HTLV-1-...
Human T cell leukemia virus type 1 (HTLV-1) basic leucine zipper factor (HBZ), which is encoded by a minus strand mRNA, is thought to play important roles in the development of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). However, ...
Adult T-cell leukemia (ATL) is a complex and multifaceted disease associated with human T-cell leukemia virus type 1 (HTLV-I) infection. Tax, the viral oncoprotein, is considered a major contributor to cell cycle deregulation in HTLV-I transformed cells by either directly disrupting cellular fac...
Insights into the complexity of HTLV pathogenicity have also been gained through recent investigations of the impact of HTLV-1 infection on the microRNA (miRNA) regulatory network. Several studies identified miRNAs that influence NF-κB signaling, cell proliferation, differentiation, and survival [39,...