缺氧是肿瘤微环境的标志，影响肿瘤恶变和治疗反应。研究通过整合单细胞RNA测序和普通转录组测序，分析缺氧相关基因表型、风险评分和预后，探讨其与HNSCC独特亚型口咽鳞状细胞癌（OPSCC）的状态及免疫属性的关系，以制定个性化治疗策略。
来自丹麦头颈癌研究组(DAHANCA)的数据显示,HPV口咽鳞癌(HPV+OPSC)在无事件进展、肿瘤局部控制、患者总生存率方面显著优于HPV阴性口咽鳞癌(HPV-OPSC)。另外RTOG9003,DAHANCA6&7,RTOG0129,ARTSCA四项临床研究的结果显示:HPV+HNSCC患者相对HPV-HNSCC患者在放疗后...
这些结果表明,7.6%的原发性HPV+ HNSCC患者发生了第二原发癌。扁桃体显示出发生第二原发肿瘤的总体风险为730倍,其中12-59个月的HPV+ HNSCC诊断风险最高。舌头患第二原发癌的风险增加了340倍,在前11个月的风险最高。 至于远处的区域,食道患第二原发癌的几率增加了6倍,而肺部的风险则增加了2倍。两者在12-59...
OPSCC中,p16对ISH阳性具有高灵敏度(100%)、特异度(91%)、以及阳性(93%)和阴性预测值(100%)。在非-OPHNSCC中,p16对ISH阳性的灵敏度(83%)和阳性预测值(40%)较低,但特异度(94%)和阴性预测值(99%)较高。 1995~2012年间,因...
The large majority are squamous cell carcinomas (HNSCC) that develop in the mucosal linings of the upper aerodigestive tract. These tumors develop either by exogenous carcinogen exposure (smoking, alcohol drinking) or by human papillomavirus (HPV) infection, particularly those in the oropharynx (OPS...
In particular, a subset of HNSCC is now known to be associated with HPV [1, 2]. These HPV-related HNSCCs (HPV-HNSCCs) occur more frequently in younger, male patients. They occur most frequently in the oropharynx, and are associated with improved clinical outcomes [3, 4]. In effect, ...
HPV-positive HNSCC cell lines but not primary human fibroblasts are radiosensitized by the inhibition of Chk1. Radiother Oncol 2013;108:495-9.Busch CJ, Kriegs M, Laban S, Tribius S, Knecht R, Petersen C, Dikomey E, Rieckmann T (2013) HPV-positive HNSCC cell lines but not primary ...
“HPV, p16, head neck”. We also included references quoted in original or review articles that may not have been found during the initial literature search. We screened the articles and included all studies of HNSCC patients which investigated survival rates by the p16 and HPV status of the ...
Despite the comparably high cure rates observed for HPV-positive HNSCC, there is still a great need for specific tumor radiosensitization due to the often severe side effects resulting from intense radiochemotherapy. We recently demonstrated that HPV-positive HNSCC cell lines are characterized by a de...
Preclinical models of HPV+ and HPV- HNSCC in mice: an immune clearance of HPV+ HNSCC Background:To investigate whether human papilloma virus (HPV)-specific immune mechanisms can result in tumor clearance, we have created HPV+ and HPV- tonsi... R Williams,WL Dong,BD Elzey,... - 《Head...