the dynamic process of cell expansion; all three parameters must change in a coordinated fashion in order to create a steady-state equilibrium that maintains the driving forces required for continued growth, including water uptake. The rate of growth is controlled by changes in cell wall ...
DNA methylation is a form of epigenetic modification of gene expression. In mammalian cells, DNA methylation commonly involves the addition of a methyl group contributed by S-adenosy-L-methionine (SAM) to CpG dinucleotides to create 5-methylcytosine (m5c), which is catalyzed by DNA methyltransferas...
Can we one day use parts to create a whole?; (B) The main reason why we would like to control living systems is to control how one cell behaves and in this way, determine what it does e.g. differentiation. The tools to achieve such fates are only beginning to come of a...
Once the membranes are fused, the viral RNA is released into the cytosol of the host cell and its first open reading frame is translated by the host ribosome machinery to create the two variants of the viral polyprotein [Citation27]. Thus begins the cascade of events that results in the ...
Dystrophin deficiency leads to the severe muscle wasting disease Duchenne Muscular Dystrophy and the milder allelic variant, Becker Muscular Dystrophy (DMD and BMD). Previous work has shown that concomitant interaction of the actin binding domain 2 (ABD2) comprising spectrin like repeats 11 to 15 (...
Camptothecin (CPT) is another genotoxic factor that has been used to study DDR in plants, e.g., in Medicago truncatula [38]. Its cytotoxic effects have been long known for plants [39]. CPT causes the induction of both SSBs and DSBs and enhances the level of cell death in plants [40,...
Pol κ also contains an N-terminal clasp domain which allows it to encircle DNA, linking the little finger and thumb, while also interacting with the primer [20]. In contrast to Pol η, Genes 2017, 8, 19 3 of 19 Pol κ has a large gap between the little finger and thumb domain ...