Villarreal DM, Do V, Haddad E, Derrick BE. NMDA receptor antagonists sustain LTP and spatial memory: active processes mediate LTP decay. Nat Neurosci. 2002;5:48–52. CAS PubMed Google Scholar Xiao MY, Niu YP, Wigström H. Activity-dependent decay of early LTP revealed by dual EPSP re...
N-Methyl D-Aspartate (NMDA) Antagonists Namenda (memantine) is the only drug in this class, and it is approved for moderate to severe Alzheimer's.4 Namenda appears to work by regulating levels of glutamate, an amino acid, in the brain. Normal levels of glutamate facilitate learning, but ...
But they aren’t convinced it’s time to ditch the NMDA receptor as a drug target for depression quite yet. “In my view, it is quite premature to move away from the hypothesis that NMDA receptor antagonists have antidepressant activity based on this single study,” said Dr. John Krystal,...
Memantine is a clinically well-tolerated N-methyl-D-aspartate (NMDA) receptor antagonist — a review of the preclinical data. Neuropharmacology 38, 735–767 (1999). Article CAS PubMed Google Scholar Gerzon, K. et al. The adamantyl group in medicinal agents. I. Hypoglycemic N-arylsulfonyl-N...
In addition, the study by Henneberger and col- leagues interestingly shows that clamping astrocytic free Ca2+ concentration at 50–80 nM, by adding 0.45 mM EGTA and 0.14 mM Ca2+ to the intra-pipette solution for patch clamp, impairs isolated NMDA receptor fEPSP and that...
We therefore repeated the above experiment in the presence of the AMPA and NMDA receptor antagonists NBQX and AP-5. Mean progressive depolarization remained virtually unchanged (5.6 ± 1.2 mV; n = 10; p = 0.001, two-tailed paired t test), and some of the neurons started firing action ...
Psychiatry. The findings, by Yale researchers working at the VA Connecticut Healthcare System and the Connecticut Mental Health Center, outline the rapid antidepressant effects of the compound. The compelling results suggest a potential role for NMDA receptor modulating drugs in the treatment of ...
A third group is more heterogeneous and includes RA agonists, Histamine H3 receptors, and Muscarinic receptor antagonists (Table 1) but also seems to have EBP or CYP51 as secondary targets. Several of these compounds have entered clinical trials, with Clemastine being the most promising (Table 2...
NMDA receptor-dependent long-term potentiation comprises a family of temporally overlapping forms of synaptic plasticity that are induced by different patterns of stimulation. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2014, 369, 20130131. [Google Scholar] [CrossRef] [Green Version] Bashir, Z...
This medicine belongs to a group called the NMDA receptor antagonists that work by lowering the levels of abnormal excitement in the brain. While Namenda is not a cure for the said disease and neither does it slow down the rate of progression, it can help the patients of Alzheimer's to ...