Juvenile myelomonocytic leukemia (JMML) is a unique, aggressive hematopoietic disorder of infancy/early childhood, due to excessive proliferation of cells of monocytic and granulocytic lineages. Approximately 90% of patients carry either somatic or germline mutations of PTPN-11, K-RAS, N-RAS, CBL or...
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Leukemia-Lymphoma, Adult T-CellHematopoietic Stem Cell TransplantationAdult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy of mature activated T cells caused by human T-cell lymphotropic virus type I. ATL carries a bad prognosis because of intrinsic chemoresistance and severe ...
Leukemia in infants is rare but generates tremendous interest due to its aggressive clinical presentation in a uniquely vulnerable host, its poor response to current therapies, and its fascinating biology. Increasingly, these biological insights are pointing the way toward novel therapeutic approaches. ...
Insulin resistance, in particular, triggers oncogenic pathways such as PI3K/AKT and MAPK, exacerbating the aggressive phenotype seen in leukemia patients with T2DM. Additionally, clonal hematopoiesis of indeterminate potential (CHIP) is implicated in the higher leukemia risk observed in diabetic ...
One serious complication in fewer than 10% of CLL patients: The leukemia transforms into a more aggressive variety of the disease. In these rare cases, treatment plans can remain similar to CLL treatment or be completely revised to attack the more aggressive form. Your oncologist will guide you...
"High-risk leukemias adopt features of blood stem cells that make them really aggressive and resistant to chemotherapy," explains Dr. Sankaran. "But normal stem cells saved Lynn's life." Targeted treatments for leukemia? Although our understanding of MECOM arrived too late to change Lynn's cou...
How Loss Of Key Protein Promotes Aggressive Form Of LeukemiaPeter Tarr
This genetic component is known as LINE-1, and its aggressive intrusion into the genome can wreak havoc, leading to disease-causing mutations. A key protein called ORF2p enables its success—meaning understanding ORF2p's structure and mechanics could illuminate new potential therapeutic targets for...