但是随着研究的不断深入,越来越多的研究表明dili的发生与个体人类白细胞抗原(humanleucocyteantigen,hla)等位基因多态性相关。它的多态性是由于同源染色体的相同位置上存在不同形态基因,即等位基因(allele)不同导致的结果。有研究通过候选基因关联研究和全基因组关联分析发现了由于特定药物引起的肝损伤与主要hla基因位点之间...
• Value of the HLA-B*5701 allele to predict abacavir hypersensitivity in Spaniards. Rodríguez-Nóvoa S, García-Gascó P, Blanco F, González-Pardo G, Castellares C, Moreno V, Jiménez-Nácher I, González-Lahoz J, Soriano V. AIDS Res Hum Retroviruses. 2007 Nov;23(11):1374-6. •...
Description: Identification of Drug Resistant Mutations: AmpliSens® Genoscreen HLA B*5701-FRT PCR kit is an in vitro nucleic acid amplification test for qualitative detection of B locus 5701 allele of human major histocompatibility complex...
Diversity of HLA-B17 alleles and haplotypes in East Asians and a novel Cw6 allele (Cw*0604) associated with B*5701 The distribution of HLA-B17 alleles and their association with HLA-A, -C and -DRB1 alleles were investigated in seven East Asian populations (Japanese, Sou... T Inoue,A Og...
Despite this, drug-responsive T-cells have not been detected and as such the role of the HLA risk allele in the disease is not known. We test the following hypothesis: drug-responsive T-cells circulate in patients with flucloxacillin-induced liver injury and the drug antigen is presented to ...
5701allele,withaprevalencerateof0.479 .Ofthe230 IDUsofHanethnic,3carriedHLA—B * 5701allele(1.30 );ofthe813IDUsofYiethnic2carriedHIA—B * 5701 allele(0.246 ).Condusion TheprevalenceofHLAB * 5701inHIVinfeetedIDUsinLiangshanwaslowerthanthat ...
Because of the strong genetic effect of inheriting an APOE4 allele, APOE4 has been referred to as a complex susceptibility gene for almost two decades. Consistent replications of the age of onset distributions as a function of APOE genotype confirm that the role of APOE3 inheritance is not ...
We assessed the proficiency of HLA-B*5701 typing among numerous laboratories using a sequence specific primer (SSP)/ PCR assay.Methods: DNA was distributed to 6 laboratories for blinded typing of the HLA-B*5701 allele. Panel A (n=10 samples; n=6 laboratories) included 3 HLA-B*5701 ...
Abacavir hypersensitivity is strongly associated with the human leukocyte antigen (HLA)-B*5701 allele; however, the cost of routine high-resolu... C.,K.,S.,... - 《Clinical Infectious Diseases》 被引量: 39发表: 2007年 Comparison of Abacavir/Lamivudine and Tenofovir/Emtricitabine Among ...
However, the risk of progression to AIDS also varies among patients carrying this specific allele. To gain a better understanding of the interplay between HIV-1 evolutionary rate variation and risk of disease progression, we followed untreated HLA-B*5701 subjects from early infection up to the ...