• Value of the HLA-B*5701 allele to predict abacavir hypersensitivity in Spaniards. Rodríguez-Nóvoa S, García-Gascó P, Blanco F, González-Pardo G, Castellares C, Moreno V, Jiménez-Nácher I, González-Lahoz J, Soriano V. AIDS Res Hum Retroviruses. 2007 Nov;23(11):1374-6. •...
但是随着研究的不断深入,越来越多的研究表明dili的发生与个体人类白细胞抗原(humanleucocyteantigen,hla)等位基因多态性相关。它的多态性是由于同源染色体的相同位置上存在不同形态基因,即等位基因(allele)不同导致的结果。有研究通过候选基因关联研究和全基因组关联分析发现了由于特定药物引起的肝损伤与主要hla基因位点之间...
( ABC HSR) reactions is an Multi - organ hypersensitivity syndrome caused by abacavirwhich has been prescribed for the treatment of HIV infection in occident in the European and American countries. In 2001 a strong pre-dictive association between carriage of HLA - B*5701 allele and abacavir ...
Description: Identification of Drug Resistant Mutations: AmpliSens® Genoscreen HLA B*5701-FRT PCR kit is an in vitro nucleic acid amplification test for qualitative detection of B locus 5701 allele of human major histocompatibility complex...
HLA-B*5701 typing: evaluation of an allele-specific polymerase chain reaction melting assay Hammond E, Mamotte C, Nolan D, Mallal S (2007) HLA-B*5701 typing, evaluation of an allele-specific polymerase chain reaction melting assay. Tissue ... E Hammond,C Mamotte,D Nolan,... - 《Tissue...
5701allele,withaprevalencerateof0.479 .Ofthe230 IDUsofHanethnic,3carriedHLA—B * 5701allele(1.30 );ofthe813IDUsofYiethnic2carriedHIA—B * 5701 allele(0.246 ).Condusion TheprevalenceofHLAB * 5701inHIVinfeetedIDUsinLiangshanwaslowerthanthat ...
We assessed the proficiency of HLA-B*5701 typing among numerous laboratories using a sequence specific primer (SSP)/ PCR assay.Methods: DNA was distributed to 6 laboratories for blinded typing of the HLA-B*5701 allele. Panel A (n=10 samples; n=6 laboratories) included 3 HLA-B*5701 ...
HLA-B*57:01 allele prevalence in treatment-Naïve HIV-infected patients from Colombia Article Open access 09 September 2019 References Park B K, Pirmohamed M, Kitteringham N R. Role of drug disposition in drug hypersensitivity: a chemical, molecular, and clinical perspective. Chem Res Toxico...
Because of the strong genetic effect of inheriting an APOE4 allele, APOE4 has been referred to as a complex susceptibility gene for almost two decades. Consistent replications of the age of onset distributions as a function of APOE genotype confirm that the role of APOE3 inheritance is not ...
Despite this, drug-responsive T-cells have not been detected and as such the role of the HLA risk allele in the disease is not known. We test the following hypothesis: drug-responsive T-cells circulate in patients with flucloxacillin-induced liver injury and the drug antigen is presented to ...