结论HLA-A*02等位基因在中国南、北汉族人群中的分布呈现高度杂合和遗传多样性并具有显著性差异,HLA-A*020101、A*0203和A*0207可作为人类学研究中区分中国南北汉族人群的遗传标志。 Abstract:ObjectiveTo investigate the distributions of HLA-A∗02 alleles in Han populations and compare their difference between ...
An assay positive control is provided (Cat#280301) that can be diluted to a high, medium, and low concentration. Signal intensity can be correlated to affinity of the peptide. What is the peptide exchange technology and what's the advantage of using it? Flex-T™ MHC monomers are ...
We eval- uated the sensitivity and positive predictive value (PPV) of IL28B and the two HLA alleles described above (HLA-A*02:01 and DRB1*11:01) with HCV clearance. As shown in Table S5, after adjusting for age and gen- der, the sensitivity of IL28B on HCV clearance was ...
Evolutionary analysis of classical HLA class I and II genes suggests that recent positive selection acted on DPB1*04:01 in Japanese population. PloS one 7, e46806, DOI:10.1371/ journal.pone.0046806 (2012). 18. Nakaji, S., Ueta, M., Sotozono, C., Inatomi, T. & Kinoshita, S. [...
ERAP1 and ERAP2 Polymorphism and Expression in A*29:02-Positive Cell Lines None of the three cell lines used in this study expressed ERAP2 (Fig. 2A). The ERAP1 protein was present in PF97387, MOU and SWEIG in the ratios 1:0.5:0.06 (Fig. 2B). The higher expression level of ERA...
In addition, PHA (250 μg/ml, Sigma-Aldrich, USA) was included as positive control. Finally, plates were revealed with biotinylated anti-human IFN-γ, streptavidin–alka- line phosphatase and its coloured substrate (Mabtech, Sweden). IFN-γ secreting cells were quantified under Immuno ...
15. Subbiah V, Wolf J, Konda B, et al. Tumour-agnostic efficacy and safety of selpercatinib in patients with RET fusion-positive solid tumours other than lung or thyroid tumours (LIBRETTO-001): a phase 1/2, open-label, basket trial. Lancet Oncol. 2022 Oct;23(10):1261-1273. ...
Albinism (OCA2) in Amerindians Homozygosity for a mutation in the P locus mapped to the human chromosome 15q11.2-12 results in tyrosinase-positive albinism (OCA2). This type of albinism ... CM Woolf - 《American Journal of Physical Anthropology》 被引量: 10发表: 2005年来源...
Indigenous people worldwide are at high risk of developing severe influenza disease. HLA-A*24:02 allele, highly prevalent in Indigenous populations, is associated with influenza-induced mortality, although the basis for this association is unclear. Here, we define CD8+T-cell immune landscapes agains...