HLA-B27 shows a marked genotypic and phenotypic polymorphism with at least 132 alleles and 105 subtypes. Non-synonymous nucleotide substitutions affecting the antigen-binding cleft can lead to differences in an
As these associations might be driven by the allele relative frequency, we sought additional evidence that some alleles are inversely correlated to JAK2 V617F disease. Indeed, bilocus haplotype analysis revealed that the haplotype HLA-A*02:01∼HLA-B*35:01 was the most significantly depleted in...
PCR-SSP subtyping for HLA-DRB4alleles was undertaken on a large panel of the British Caucasoid population (n=238) to ascertain the frequency and linkage disequilibrium of HLA-DRB4subtypes with their associated HLA-DRB1(DRB104, DRB10701, DRB109011) and HLA-DQB1alleles.Our findings indicate that...
Overall, we found that 95.8% of individu- als with CD were DQ2 and/or DQ8 positive, as compared with 32.5% of the healthy individuals, a result similar to those in other Caucasian populations (15–16,19). This result is very important in terms of diagnostic policies in Greece, given ...
Compared to the expected allele frequency database values, there are some discrepancies in the proportions regarding the populations. While the most common al- lele for HLA-B is B*07:02 and indeed is the most com- mon in the Caucasian population according to the database, the rest of the...
A total of 329 families with 329 women, 131 men, and their 331 newborns were enrolled at baseline (36 weeks of pregnancy) between years 1998 and 2002 and were followed up for 6 years. The cohort represents Caucasian origin as the Finnish population has the same ethnic background. ...
After Bonferroni corrections, the frequencies of phenotypes A*24, B*14, and B*40 were significantly greater in index cases, and the frequency of B*62 was significantly lower in index cases. The most common haplotypes in index cases were A*02-B*44 (frequency 0.1385), A*01-B*08 (...
HLAAlleleassociatedtoADR SJS/TEN*HLA-B*1502 Allopurinol别嘌呤醇(治痛风)Gout(痛风病)SJS/TEN*HLA-B*5801 SJS:Steven-Johnson综合症TEN:毒性皮肤坏死(ToxicEpidermalNecrolysis)HLA-B*1502PrevalentinAsia TheriskofSJS/TENisestimatedtobeabout1to6per10,000newusersincountrieswithmainlyCaucasian...
1) of Caucasian (A), Asian (B) or African/Caribbean ancestry (C). D: HLA-DR2h, E: HLA-DR3h and F: HLA-DR7h and other alleles according to the ancestry group. Ancestral variation was observed for HLA-DR2h and HLA-DR3h (Fig. 2B–F). Within the HLA-DR2h, HLA-DQA∗01:02...
sequence listing, wherein the peptide has the ability to bind to a molecule of the human major histocompatibility complex (MHC) class-I, comprising but not limited to the HLA allele expressed most frequently in Caucasian populations, HLA-A2 (including subtypes of HLAA2, such as HLA-A*0201)....