Alzheimer's disease has begun to attract the attention of national leaders around the world. As a disease that primarily affects elderly adults, it is growing in importance as the world's population ages. In fact, as life expectancy increases on a yearly basis and as baby boomers begin ...
This paper discusses the history of dementia and Alzheimer's disease (AD) with emphasis on the individuals who have shaped its development. In addition to the best known protagonists recognized as founders of the field, it will mention other figures who have provided important contributions but are...
Alzheimer disease: maternal history of Alzheimer disease correlates with amyloid-beta deposition.Yates D.doi:10.1038/nrneurol.2010.60YatesDarranNat Rev NeurolNature Reviews Neurology
Alzheimer’s disease (AD) is an irreversible progressive neurological disorder that is characterized by memory loss, the retardation of thinking and reasoning, and changes in personality and behaviors.1,2AD seriously endangers the physical and mental health of the elderly. Aging is the biggest risk ...
Data from case-control studies of Alzheimer's disease (AD) were pooled to examine the possible roles of history of depression, anti-depressant treatment and adverse life events as risk factors. History of depression was found to be associated with AD, although the effect was confined to late ...
INTRODUCTION: Family history (FH) of Alzheimer's disease (AD) affects mitochondrial function and may modulate effects of translocase of the outer mitochondrial membrane 40 kDa (TOMM40) rs10524523 ('523) poly-T length on memory decline. METHODS: For 912 nonapolipoprotein ε4 middle-aged adults ...
OBJECTIVE--Type 2 diabetes in midlife or late life increases the risk of Alzheimer disease (AD), and type 1 diabetes has been associated with a higher risk of detrimental cognitive outcomes, although studies from older adults are lacking. We investigated whether individuals with AD were more like...
History: 65-year-old man with memory loss Diagnosis: Alzheimer disease (with disproportionate parietotemporal and hippocampal atrophy & positive Amyvid scan). Notes: 1. disproportionate [ˌdɪsprəˈpɔ:rʃənət] adj. 不成比例的 ...
Apathy is a common behavioral symptom of dementia, yet information on its impact dementia is limited. This study examines prevalence, incidence, and persistence of apathy longitudinally. Sample was drawn from the National Alzheimer's Coordinating Center Uniform Data Set (NACC︰DS) including ...
Alzheimer’s disease (AD) pathology develops many years before the onset of cognitive symptoms. Two pathological processes—aggregation of the amyloid-β (Aβ) peptide into plaques and the microtubule protein tau into neurofibrillary tangles (NFTs)—are hallmarks of the disease. However, other pathol...