Metabolic Regulation of Gene Expression by Histone Lysine beta-Hydroxybutyrylation. Molecular cell 62, 194-206, https://doi.org/10.1016/j.molcel.2016.03.036 (2016).Xie, Z. Y. et al. Metabolic regulation of gene expression by histone lysine beta- hydroxybutyrylation. Mol. Cell 62, 194-206 ...
Histone lysine de-β-hydroxybutyrylation by SIRT3doi:10.1038/s41422-019-0211-2Susan M. AbmayrJerry L. WorkmanCell Research
Histone lysine crotonylation is a posttranslational modification with demonstrated functions in transcriptional regulation. Here we report the discovery of a new type of histone posttranslational modification, lysine methacrylation (Kmea), corresponding
Neoglycoproteins: in vitro introduction of glycosyl units at glutamines in beta-casein using transglutaminase. Biochemistry. 1984;23(16):3759–65. 3. Garrity J, Gardner JG, Hawse W, Wolberger C, Escalante-Semerena JC. N-lysine propionylation controls the activity of propionyl-CoA syn‑ ...
Luo W, Yu Y, Wang H et al (2020) Up-regulation of MMP-2 by histone H3K9 β-hydroxybutyrylation to antagonize glomerulosclerosis in diabetic rat. Acta Diabetol https://doi.org/10.1007/s00592-020-01552-2 Miyamoto J, Ohue-Kitano R, Mukouyama H et al (2019) Ketone body receptor GPR43...
Butyrylation Kcr: Lysine crotonylation Kbhb: Lysine β-hydroxybutyrylation KGDHC: α-ketoglutarate dehydrogenase complex Kglu: Lysine glutarylation Khib: Lysine 2-hydroxyisobutyrylation Kla: Lysine lactylation Kma: Lysine malonylation KO: Knockout ...
beta-hydroxybutyrateBDNFEpigenetics regulation has been considered a mechanistic interface between environmental stress stimuli and altered functioning of underlying gene network. Metabolite changes in vivo after stress contribute to histone modification. Histone3-lysine9-beta-hydroxybutyrylation (H3k9bhb), a ...
Crotonylation of proteins is a newly found type of post-translational modifications (PTMs) which occurs leadingly on the lysine residue, namely, lysine crotonylation (Kcr). Kcr is conserved and is regulated by a series of enzymes and co-enzymes including
Lysine succinylation is one of the major post-translational modifications occurring on histones and is believed to have significant roles in regulating chromatin structure and function. Currently, histone desuccinylation is widely believed to be catalyze
Proteomic analysis of histones has shown that they are subject to a superabundance of acylations, which extend far beyond acetylation, to include: crotonylation, propionylation, butyrylation, malonylation, succinylation, β-hydroxybutyrylation and 2-hydroxyisobutyrylation. To date, much of the functiona...