PrognosisTherapyThe HER-2/neu oncogene encodes a transmembrane tyrosine kinase receptor with extensive homology to the epidermal growth factor receptor. HER-2/neu has been widely studied in breast cancer. In this review, the association of HER-2/neu gene and protein abnormalities studied by ...
Breast cancerHER2brain metastasesSeveral retrospective studies have illustrated the correlation between HER2 overexpression and increased risk of metastatic disease and poor prognosis in breast cancer. In a retrospective study, we evaluated the risk of brain metastases in these patients. Medical charts of ...
针对HER-2低表达乳腺癌患者,《JAMA Oncology》杂志发表了一篇题为《Clinicopathologic Characteristics and Prognosis of ERBB2-Low Breast Cancer Among Patients in the National Cancer Database》的研究。该研究分析了美国国家癌症数据库中HER-2低表达患者...
chemotherapy and radiation are the most important treatments for Her-2 negative breast cancer due to poor targeted therapy.Neoadjuvant chemotherapy has many advantages, for example, it can reduce tumor stage,to achieve surgical operation,maintain breast and armpit, and provide sensitive...
2023年8月, Frontiers in Oncology杂志发表了一项研究,题为《HER-2 ultra-low breast cancer: exploring the clinicopathological features and prognosis in a retrospective study》,为我们提供了关于HER-2超低表达乳腺癌的深入分析。 研...
Anti-HER-2 targeted therapy was the standard treatment for HER-2-positive breast cancer. The application of monoclonal antibody, such as trastuzumab, has significant improved the prognosis of HER-2 positive breast cancer patients. Additionally, researches on noval HER-2 targeted drugs including mAbs...
Overexpression of the c-erbB-2 (HER-2/neu) oncogene, which encodes a transmembrane receptor tyrosine kinase, has been shown to be associated with poor prognosis in ovarian and breast cancer. Recent studies indicate that c-erbB-2 may also... JG Hengstler,J Lange,A Kett,... - 《Cancer ...
Evaluation of HER-2/neu gene amplification and protein expression in non-small cell lung carcinomas. HER-2/neu gene amplification and celt surface overexpression are important factors in breast cancer for prognosis and prediction of sensitivity to anti-HER... Hirsch,R F.,Varella-Garcia,... -...
本文围绕HER-2阳性乳腺癌患者的抗HER-2靶向药物及个体化治疗治疗做一综述。Abstract:Withthedeepeningofmolecularbiologyresearch,breakthroughshavebeenmadeintheresearchandclinicalapplicationoftumortargetedtherapy.TheHER-2genehasimportantguidingvalueinthediagnosis,treatmentandevaluationofprognosisofbreastcancer.Thisarticle...
孕激素受体对HER-2阴性乳腺癌患者转移和预后的影响(Influence of progesterone receptor on metastasis and prognosis in breast cancer patients with negative HER-2) 内容亮点 探讨转移性乳腺癌不同单一阳性激素受体亚型[雌激素受体(ER)...