Most of the false positive results (AI < 30 among cases known not to have had recent infection) were detected among known resolved infections, in both the plasma and DBS; as a result, a testing algorithm has been designed incorporating both PCR and two dilution factors. The sensitivity and ...
A treatment algorithm for chronic hepatitis B virus (HBV) infection was developed by a panel of US hepatologists based on new developments in the understanding of the virology of HBV, availability of more sensitive molecular diagnostic testing, and advantages and disadvantages of currently approved ...
Multiplex viral nucleic acid testing (NAT) and a discriminatory testing algorithm have been used to detect viral infections in blood donors. Non-discriminated reactive (NDR) results may arise from low hepatitis B virus (HBV) DNA levels and are challenging for donor management by blood services. ...
Currently, treatment monitoring is carried out using quantitative RNA testing, but the SVR standard allows for qualitative tests using RNA or viral protein if they meet sensitivity standards. Fig. 2 Standard testing algorithm for HCV screening Full size image...
79,80 Whether or not there should be screening for occult HBV infection in pregnant women living in areas of high HBV endemicity by using sensitive assays for HBV DNA is a matter of current study. Treatment An algorithm for management of HBV for pregnant persons is described in Fig. 27.2....
An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. Histological activity reflects the global assessment of basic necroinflammatory lesions and is a criterion of major importance in chronic hepatitis C. The ... P Bedossa,T Poynard - 《Hepatology...
Testing of serum samples of 23 pregnant women who were asymptomatic carriers of hepatitis B surface antigen for e antigen and antibody to e with an immunod... K Okada,I Kamiyama,M Inomata,... - 《New England Journal of Medicine》 被引量: 1559发表: 1976年 Type B hepatitis after needle-...
This paper presents a new procedure for vaccine design against highly variable viruses such as Hepatitis C. The procedure uses an optimization algorithm to design vaccines that maximize the coverage of epitopes across different virus variants. Weighted epitopes based on the success ratio of immunological...
Figure 54.1.CDC recommended hepatitis C testing algorithm. *Additional testing should be done as appropriate. In addition to their utility for confirmation, NAT assays are used for monitoring treatment response (quantitative HCV NAT) and as prognostic assays to predict response to treatment (genotyping...
In general, the algorithm for testing and diagnosis of HCV infection begins with an antibody test in accordance with guidelines and recommendations provided by the AASLD in 200961 and the US Centers for Disease Control and Prevention in 2013.62 Screening tests for HCV are recommended in children ...