Of HIV-specific/ART-specific characteristics, only history of an AIDS-defining illness was more common among persons with steatosis/NAFLD. After adjusting for age, sex and race/ethnicity, BMI greater than 30kg/m2, HOMA-IR greater than 2.0, Metabolic syndrome and each of its components were ...
Background & AimsThe diagnostic accuracy of hepatic ultrasonography for detection and grading of hepatic steatosis in children with suspected nonalcoholic fatty liver disease (NAFLD) remains poorly characterized. The aim of this study was to prospectively evaluate the clinical utility of ultrason...
Retinoic acid (RA), an active metabolite of vitamin A (retinol), has been implicated in the regulation of lipid metabolism and hepatic steatosis in animal models. However, the relation between RA and liver histology in patients with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steato...
Toledo, F. G., Sniderman, A. D. & Kelley, D. E. Influence of hepatic steatosis (fatty liver) on severity and composition of dyslipidemia in type 2 diabetes.Diabetes Care.29, 1845–1850 (2006). ArticlePubMedGoogle Scholar Verschoor, L., Chen, Y. D., Reaven, E. P. & Reaven, G....
Indeed, although the contribution of liver ERα in preventing or limiting the diet-induced hepatic steatosis/NAFLD in the two sexes has not been investigated, this hypothesis is supported by recent reports highlighting the negative correlation between hepatic ERα expression/activity and fatty liver [...
The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular senescence refers to a state of irreversible cell-cycle arrest combined with the secretion of proinflammatory cytokines and mitochondrial dysfunction. Senescent cells
Furthermore, aliskiren activated the fatty acid oxidation genes in the liver and skeletal muscle, which might play a role in lowering serum fatty acids and steatosis. Therefore, the clinical use of aliskiren treatment in patients with NAFLD may be promising. Materials and Methods Animals. ...
Insulin resistance is a very significant contributor to the development of NASH that is then exacerbated by hepatic steatosis (4., 5., 6.). Furthermore, strong evidence exists demonstrating that in NAFLD patients, insulin does not suppress adipose tissue lipolysis to the same extent that it ...
Nonalcoholic fatty liver disease (NAFLD) includes simple steatosis, nonalcoholic steatohepatitis (NASH), hepatic fibrosis, and cirrhosis. There is approximately 30% of the US population with NAFLD annually [69]. AMPK also attenuates lipid accumulation in murine hepatocytes and mice fed a high fructos...
Conversely, overexpression of PCSK9 in vitro dramatically attenuated the effects of metformin on hepatocyte steatosis. To our knowledge, this is the first report on the involvement of PCSK9 in olanzapine-induced NAFLD as well as in the therapeutic effect of metformin for this condition. To be ...