Friedreich’s ataxia is an autosomal recessive disorder with a prevalence of 1 in 40,000 [108]. It is characterized clinically by progressive neurodegeneration, cerebellar ataxia, cardiomyopathy, and heart failure [108]. At the molecular level, a genetic defect in the frataxin gene (FXN) leads...
Effect of a collaborative care intervention vs usual care on health status of patients with chronic heart failure: the CASA randomized clinical trial. JAMA Intern Med. 2018;178(4):511-519. doi:10.1001/jamainternmed.2017.8667 ArticlePubMedGoogle Scholar 5. Rogers JG, Patel CB...
chronic heart failure is one of the heaviest health-related burdens. In addition to the standard neurohormonal blockade therapy, several medications have been developed for chronic heart failure treatment, but the population-wide improvement in chronic heart failure ...
To ascertain relationships between the PCs and disease, we tested their associations with seven major cardiometabolic diseases: heart failure (HF), myocardial infarction (MI), f (AF, HCM, DCM, 2ndor 3rddegree atrioventricular (AV) block and diabetes, adjusting for covariates using logistic regressio...
To gain mechanistic insight, one of the identified upregulated circRNAs with a high reduction of editing in heart failure, AKAP13, was further characterized. ADAR2 reduced the formation of double-stranded structures in AKAP13 pre-mRNA, thereby reducing the stability of Alu elements and the ...
Cardiovascular diseases, including heart failure, are the most common cause of death globally. Recent studies support a high degree of comorbidity between heart failure and cognitive and mood disorders resulting in memory loss, depression, and anxiety. W
This regulates anti-hypertrophy gene program in the heart thus controlling progression to heart failure [39]. However, Star-PAP regulates multiple cellular functions such as DNA damage, oxidative stress response, apoptosis, tumorigenesis and cellular processes in cancer progression such as proliferation,...
Excessive accumulation of collagen in both the infarcted and non-infarcted areas can however lead to ventricular stiffness and heart failure [25]. Several types of collagen have been identified in the heart so far [26–28]. Among them, collagens 1 and 3 are the most widely expressed, ...
This finding prompted us to consider if the mechanism worked in heart failure (HF). We studied the regulation of SERCA2a by Lut in failing cardiomyocytes and intact heart of rats. Improvement of contractility and the mechanisms centered on SERCA2a were studied in isolated cardiomyocytes and intact...
Spectral analysis of fluctuations in heart rate: an objective evaluation of autonomic nervous control in chronic renal failure. Nephron 1987; 45: 202–206. Article CAS PubMed Google Scholar Niemelä MJ, Airaksinen KJ, Huikuri HV . Effect of beta-blockade on heart rate variability in patients...