M. et al. Development and characterization of hepatitis C virus genotype 1–7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs. Hepatology 49, 364–377, doi: 10.1002/hep.22673 (2009). 45. Anggakusuma et al. Turmeric curcumin inhibits...
Therefore, to induce strong T cell responses and to overcome the drawbacks of vaccination using recombinant virus, we applied DNA vaccine technology to develop first-in-class preventive HCV vaccine. We assessed a DNA vaccine targeting the HCV non-structural antigens, NS3, NS4, and NS5, and ...
View PDFView articleView in ScopusGoogle Scholar Chamberlain et al., 1997a R.W. Chamberlain, N. Adams, A.A. Saeed, P. Simmonds, R.M. Elliott Complete nucleotide sequence of a type 4 hepatitis C virus variant, the predominant genotype in the Middle East J. Gen. Virol., 78 (1997), ...
Introduction of NS5A mutations enables subgenomic HCV replicon derived from chimpanzee-infectious HC-J4 isolate to replicate efficiently in Huh-7 cells. J Viral Hepatitis. 2004;11:394–403.S.Maekawa, N.Enomoto, N.Sakamoto, M.Kurosaki, E.Ueda, T.Kohashi, H.Watanabe, C.-H.Chen, T.Yamashiro...
The ketoamides have been the most successful class of covalent inhibitors. Among them, the most clinically advanced are boceprevir and telaprevir [62]. The new AASLD guidelines suggest addition of the NS3/NS4A inhibitors boceprevir or telaprevir to optimize treatment for patients infected with ...
View PDFView articleGoogle Scholar [10] R.K. Sterling, E. Lissen, N. Clumeck, et al. Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection Hepatology, 43 (2006), pp. 1317-1325, 10.1002/hep.21178 Google Scholar [11] European Associ...
Double- and triple-positive tumor markers predict early recurrence and poor survival in patients with hepatocellular carcinoma within the Milan criteria and child-pugh class A. J Gastrointest Surg 2017;21:957–966 66. D'Ambrosio R, Aghemo A, Rumi MG, Primignani M, Dell'Era A, Lampertico P...
class 1 12 12 1 1 123 5 1 65 7 1 12 NS5A 12 12 1 19 1 1 9 1 1 15 1 15 1 1 25 2 1 11 4 NS5B 1 1 42 24 242 14 6 8 2 2 1 17 Drug used DCV LDV OMV SOF DSV RAVs P58S E62D Y93H Y93C Y93N Y93R K24G K24R M28A M28G M28T Q30G Q30H Q30L Q30R Q30K...
Interestingly, we found NS3/4A-specific T-cell responses in 3 out of 12 patients at week 24 after the last immunization.15 To be able to monitor CD8+ T-cell responses after NS3/4A DNA immunization in mice, MHC class I CTL epitopes had to be identified. We used the H-2b and H-2d ...
11.The method according to claim 10, wherein said sample or equipment is selected from a body fluid, biological tissue, a surgical instrument, a surgical garment, a laboratory instrument, a laboratory garment, a blood or other body fluid collection apparatus; a blood or other bodily fluid stor...