A hepatitis C virus (HCV) plasmid vaccine was constructed, based on class II-associated invariant chain peptide (CLIP) substitution which endogenously targets HCV non-structure protein 3 (NS3) CD4+ T helper 1(Th1) epitope (1248AA-1261AA) to major histocompatibility complex (MHC) class II antig...
The SAR study indicated that the introduction of electron-donating substitutions on the benzene ring was helpful for the anti-HCV activity, and the unsaturated 11-side chain might not be favorable for the activity. This study provided powerful information on further strategic optimization and ...
Sensorgrams were recorded for injections of 60 μL at 30 μL/min of solutions of sE2661 ranging in concentration from 1.5 nM to 100 nM in 2-fold increments. Kinetic constants were determined using 4000 Evaluation Software v1.0. Fab fragments were prepared by LysC endoprotease cleavage of ...
solutions or suspensions may also contain a long-chain alcohol diluent or dispersant, such as carboxymethyl cellulose or similar dispersing agents which are commonly used in the formulation of pharmaceutically acceptable dosage forms including emulsions and suspensions. Other commonly used surfactants, such ...
These oil solutions or suspensions may also contain a long-chain alcohol diluent or dispersant, such as carboxymethyl cellulose or similar dispersing agents which are commonly used in the formulation of pharmaceutically acceptable dosage forms including emulsions and suspensions. Other commonly used ...
P670. Autoimmune hepatitis type 2 and HCV infection: Study of HLA-class II antigensautoimmune hepatitis type 2 and hcv infection: study of hla-class ii antigens.doi:10.1016/0198-8859(96)85365-1A JuradoB CárdabaP JaraL HierroP Palomino...
A SumoBrain Solutions Company The present invention is based on the discovery of an association between the SNP genotype at the rs12979860 locus in the IL28B gene promoter and the probability of achieving a SVR in HC V-infected patients that are given a triple therapy treatment that contains ...
Example 11 Preparation of the Compound of Formula (XI) 11.49 g (34.58 mmol) of the compound of formula (VIII) and 9.52 g (36.30 mmol) triphenylphosphine were added to a solution of the compound of formula (VII) in toluene (34.58 mmol compound of formula (VII) for 184.86 g solution). ...
A SumoBrain Solutions Company Disclosed is a process for the preparation of a cinchonidine salt of formula (IV) via an aqueous solution of a racemic 4-hydroxy-1,2-cyclopentanedicarboxylic acid, which is subjected to cyclization without removing water, by the addition of a water-miscible organic...