Download: Download full-size image Fig. 1. Graphical representation of the hexameric bundles of p7 (GT 1a) using protocol 1(A), protocol 2 (B) and protocol 3 (C) as outlined in the text. The structures are shown at the initial stage of 0 ns of the MD simulation and at the end at...
Download: Download full-size image Fig. 1. Proposed algorithm to select patients who can be discharged from specialised care after SVR. ∗MASLD: hepatic steatosis and at least one cardiometabolic risk factor (overweight, pre/diabetes mellitus, arterial hypertension, dyslipidemia).34 DAAs, direct-ac...
A hepatitis C virus (HCV) plasmid vaccine was constructed, based on class II-associated invariant chain peptide (CLIP) substitution which endogenously targets HCV non-structure protein 3 (NS3) CD4+ T helper 1(Th1) epitope (1248AA-1261AA) to major histocompatibility complex (MHC) class II antig...
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The SAR study indicated that the introduction of electron-donating substitutions on the benzene ring was helpful for the anti-HCV activity, and the unsaturated 11-side chain might not be favorable for the activity. This study provided powerful information on further strategic optimization and ...
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Download: Download Acrobat PDF file (5MB) Supplementary materialsReferences [1] D.W. Bradley Studies of non-A, non-B hepatitis and characterization of the hepatitis C virus in chimpanzees Curr. Top. Microbiol. Immunol., 242 (2000), pp. 1-23 CrossrefView in ScopusGoogle Scholar [2] R. ...
For the 8- and 12-week treatment durations, 16% and 2%, respectively, were coinfected with HIV-1, 11% had F3 fibrosis, and 59% had plasma HCV RNA >1 × 106 IU/ml at the baseline visit. Most patients (80–83%) had no baseline drug class-specific amino acid polymorphisms in...
11.The method according to claim 10, wherein said sample or equipment is selected from a body fluid, biological tissue, a surgical instrument, a surgical garment, a laboratory instrument, a laboratory garment, a blood or other body fluid collection apparatus; a blood or other bodily fluid stor...
Introduction of a glycosylation site into a secreted protein provides evidence for an alternative antigen processing pathway: transport of precursors of major histocompatibility complex class I-restricted peptides from the endoplasmic reticulum to the cytosol J Exp Med. 186:479-87. 3. Belyakov, I. ...