Cyclophilins (Cyps) are attractive targets for broad-spectrum antivirals11,12 because divergent viruses depend on them as cofactors, including human immunodeficiency virus (HIV)13 and hepatitis C virus (HCV)14. There is also evidence for the involvement of CypA in dengue virus (DENV)15, coronavi...
The expressed protein could co-localize in endo-membrane system with BALB/c mouse MHC class II molecule I-Ad. The recombinant invariant chain molecule could aggregate with BALB/c mouse I-Ad molecule and form the theoretical nonomer structure in the COS-7 cell line. The assembled molecules ...
HCV infection leads in 50 to 80% of cases to chronic hepatitis, liver cirrhosis, or hepatocellular carcinoma. Interferons and the nucleoside analog ribavirin form the basis for treatment but are not sufficiently effective and have numerous side effects.
Fibrosis score was F0-F3 in 15 patients and cirrhosis in the remaining 11 (all in Child-Pugh class A). All had been receiving ART, and all were treated with DAAs. Only patient who had not achieved HIV viral suppression for non-compliance also experienced a relapse of HC...
For a long time, the study of the HCV infectious cycle has been a major challenge for researchers because of the difficulties in generating an efficient cell culture system leading to a productive viral infection. The development of HCVpp and later on HC
An integrated efficacy analysis of 8- and 12-week G/P therapy in patients without cirrhosis with HCV GT 1–6 infection was performed. Methods Data were pooled from nine phase II and III trials including patients with chronic HCV GT 1–6 infection without cirrhosis who received G/P (300...
HCV12(sequence ID NO: 11) gtatgagtgtcgAacagcctccagg 5a HCV13(sequence ID NO: 12) ccgggtcctttcCattggatcaaa 6a HCV14(sequence ID NO: 13) agtggtctgcggAaccggtgagtac Reacting with all types (positive control) HCV15(sequence ID NO: 14) ggtctgcggGaccggtgag No reacting with any types(ne...
12.McHutchison JG, Nainan OV, Alter MJ, Sedghi-Vaziri A, Detmer J, Collins M, Kolberg J. Hepatitis C and G co-infection: response to interferon therapy and quantitative changes in serum HGV-RNA.Hepatology. 1997;26:1322-1327.[PubMed][Cited in This Article:2] ...
[1], [10], [11] HCV entry into hepatocytes occurs through the coordinated interactions between the HCV E1–E2 heterodimer and at least four essential cellular factors: CD81,12 scavenger receptor B type I,13 occludin[14], [15] and claudin 1 (CLDN1).16 In particular, the HCV E2 ...
(11) —CONH—(CH2)1—Ra10 (wherein Ra10 is a C1-6 alkyl group optionally substituted by 1 to 3 substituents selected from the following group A, a C1-6 alkoxycarbonyl group or a C1-6 alkanoylamino group, and 1 is 0 or an integer of 1 to 6), (12) —ORa11 (wherein Ra11 ...