Pipettes (borosilicate glass; 2–3 MΩ resistance) were filled with solution containing (mM): K-gluconate 125, KCl 20, NaCl 10, amphotericin-B 0.44, HEPES 10; pH 7.2 (adjusted with KOH). Cell membrane capacitance (Cm) was determined by dividing the time constant of the decay of the ...
WRITE NET Ionic Equations for the reactions of H_2PO_4^-, a Classify each reactant and product in the given chemical reaction as a Bronsted-Lowry acid, a Bronsted-Lowry base, or neither. Arrange the species in the given reaction...
+and K+, termed Ifin the heart and Ihin neurons. Altered function of HCN channels, mainly HCN4, is associated with sinus node dysfunction and other arrhythmias such as atrial fibrillation, ventricular tachycardia, and atrioventricular block. In recent years, several data have also shown that dys...
Caution should however be exercised in interpreting such results in terms of the altered ionic mechanism underlying pacemaker activity, as well as the diverse pharmacological activity of propofol. β-adrenergic stimulation potentiates not only HCN-mediated If but also other ionic currents, including CaV...