图16.PD-L1/MSI/MMR的关系 测定了22592例多癌种患者中PD-L1/TMB/MSI的关系,两个以上Biomarker阳性的患者人群数量占比较高,也体现出联合检测指标在临床患者中的重要性。不同肿瘤中PD-L1阳性、TMB-H、MSI-H扩增的发生率差异大,当这些...
HCC的特征表现为多种细胞代谢的改变,这些改变导致血液中可辨识的物质的形成,包括胆汁酸、磷脂类、肽类、鞘脂类、活性氧物质、氨基酸、长链肉碱以及修饰核苷(例如1-甲基腺苷M1A)等。通过对203例经MRI确诊为肝硬化患者(其中37例患者进展为HCC)的612份血清样本进...
在HCC的检测过程中,临床症状、影像学检查以及血清蛋白生物标志物的应用不可或缺。通常,用于检测HCC的血清蛋白生物标志物包括甲胎蛋白(AFP)、去γ-羧基凝血酶原(DCP)以及肝细胞癌相关抗原3(GPC-3)。然而,HCC的高度异质性导致了诊断和治疗的有效率有限。随着二代测序(NGS)技术的问世以及精准医学的不断发展,组学数据...
AFP (alpha-fetoprotein) is the most widely used serum biomarker to detect HCC worldwide. However, no AFP elevation have been found in many HCC and AFP analysis can't be used to screen HCC in these cases. Currently, many studies have been carried out to find reliable biomarker in ...
AFP-L3 values are also correlated to pathologic features of HCC such as infiltrative tumor growth pattern, capsule infiltration, and vascular invasion [7].The Japan Society of Hepatology recommends the use of ultrasound and biomarkers, including AFP-L3, AFP and des-gamma-carboxy prothrombin (DCP)...
Carole Sourbier.Plasma HSP90α and liver cancer: a potential biomarker?EBioMedicine. 2017 Nov; 25: 7–8.
But also based on the results from both REACH as well as REACH-2, I think it’s fair to say this is the first biomarker-selected trial where we were able to enrich the clinical efficacy in patients with hepatocellular carcinoma. We also know the high-AFP expressor is actually occurring in...
6. 统计分析用的SPSS或R的rms包,X-tile用来取rad-score的cut-off值(X-tile是一种可以区别肿瘤亚群、判定biomarker和结局关联性强度的工具,非常想学)。其他方法包括生存KM曲线、COX回归、C-index、校正曲线、诺谟图。 个人感悟:可以看出丰富的方法学手段为一个简单的idea添砖加瓦,锦上添花,提升档次。
###MMP9 confers a valuable therapeutic target and biomarker for immunotherapy in HCC These investigations inspired ### 这些研究启发作者提出了一种针对MMP9的新疗法。作者开发了一种新的抗MMP9兔单克隆抗体(mAb),并评估了其在临床实践中用于免疫治疗的潜在治疗价值。单独使用抗PD-1或抗MMP9单药治疗在一定程...
AFP阴性HCC早期筛查和诊断的生物标志物研究进展 【摘要】肝细胞癌的早期诊断和有效治疗对提高生存率和改善预后至关重要。甲胎蛋白是目前应用最广的诊断肝细胞癌的生物学标志物,但临床中发现甲胎蛋白易受一些非肝细胞癌疾病的影响[1],对...