MPNs arise as a consequence of clonal proliferation driven by at least one somatically acquired driver mutation. Of these, the most recurrent is JAK2V617F, which occurs in 495% of PV and 50–60% of ET and PMF cases. In patients without JAK2 mutations, somatic mutations in CALR are the ...
which tags the 46/1 haplotype (PAR=17.4% compared with 11.8% for the tightly linked SNP rs12340895 inJAK2V617FandMPLmutation negative cases from our previous