2 HALLMARK_ANGIOGENESIS 36 3 HALLMARK_HEDGEHOG_SIGNALING 36 4 HALLMARK_PANCREAS_BETA_CELLS 44 5 HALLMARK_APICAL_SURFACE 46 6 HALLMARK_WNT_BETA_CATENIN_SIGNALING 50 7 HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY 58 8 HALLMARK_TGF_BETA_SIGNALING 59 9 HALLMARK_MYC_TARGETS_V2 60 10 HALLMARK_CHOLESTEROL_H...
Koesters, R. et al. Mutational activation of the beta-catenin proto-oncogene is a common event in the development of Wilms’ tumors.Cancer Res.59, 3880–3882 (1999). CASPubMedGoogle Scholar Nusse, R. & Clevers, H. Wnt/β-catenin signaling, disease, and emerging therapeutic modalities.Cell...
4 HALLMARK_PANCREAS_BETA_CELLS 44 5 HALLMARK_APICAL_SURFACE 46 6 HALLMARK_WNT_BETA_CATENIN_SIGNALING 50 7 HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY 58 8 HALLMARK_TGF_BETA_SIGNALING 59 9 HALLMARK_MYC_TARGETS_V2 60 10 HALLMARK_CHOLESTEROL_HOMEOSTASIS 77 11 HALLMARK_PROTEIN_SECRETION 98 12 HALLMARK_A...
1 HALLMARK_NOTCH_SIGNALING 34 2 HALLMARK_ANGIOGENESIS 36 3 HALLMARK_HEDGEHOG_SIGNALING 36 4 HALLMARK_PANCREAS_BETA_CELLS 44 5 HALLMARK_APICAL_SURFACE 46 6 HALLMARK_WNT_BETA_CATENIN_SIGNALING 50 7 HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY 58 8 HALLMARK_TGF_BETA_SIGNALING 59 9 HALLMARK_MYC_TARGETS_V...
50 WNT_BETA_CATENIN_SIGNALING signaling canonical beta catenin pathway 49 42 Examples Using the Hallmark Collection In this section, we give three examples that illustrate different aspects of the use of the hallmark collection for GSEA. The first example shows how using only the hallmarks can form...
Researchers have begun to understand the process that allows certain cancer cells to become dormant for periods of time and emerge later with recurring disease. These cancer cells enter a state of latency and slow division by inhibiting a WNT protein-driven signaling pathway.246In addition, these ...
Researchers have begun to understand the process that allows certain cancer cells to become dormant for periods of time and emerge later with recurring disease. These cancer cells enter a state of latency and slow division by inhibiting a WNT protein-driven signaling pathway.246In addition, these ...
When Wnt signal is active, the Frizzled receptor turn off the GSK3-beta that cannot phosphorylate β-catenin which stabilizes and shuttles to the nucleus where it activates the TCF/LEF (T-Cell Factor/Lymphoid Enhancer Factor) transcription factor complex involved in promoting the transcription of ...
1 HALLMARK_NOTCH_SIGNALING 34 2 HALLMARK_ANGIOGENESIS 36 3 HALLMARK_HEDGEHOG_SIGNALING 36 4 HALLMARK_PANCREAS_BETA_CELLS 44 5 HALLMARK_APICAL_SURFACE 46 6 HALLMARK_WNT_BETA_CATENIN_SIGNALING 50 7 HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY 58
induced on the surface of damaged cells by activated tumour suppressors, such as TP53. Death receptor ligation promotes death-inducing signaling complex formation, resulting in cleavage-activation of caspases 8 or 10, leading either to direct cell-death via effector caspases 3 and 7 or, in conditi...