15 2 一,概述 (一)前言 移植物抗宿主病(graft-versus-host disease, GvHD)是异基因 造血干细胞移植(allogeneic hematopoietic stem cell transplantation, Allo-HSCT)后,受者在重建供者免疫的过程中,来源于供者的 淋巴细胞攻击受者组织发生的一类多器官综合征,表现为主要 累及皮肤,胃肠道,肝,肺和黏膜表面的组织...
Graft versus host disease (GVHD) is induced by donor immunocompetent T lymphocytes transferred into allogeneic hosts incapable of rejecting them. It is a consequence of the interactions between antigen-presenting cells (of both recipient and donor origin) and mature T-lymphocytes of the donor. GVHD...
移植物抗宿主病(graft versus host disease)简称GVHD。是由于移植物的抗宿主反应而引起的一种免疫性疾病。分急性和慢性二种。 诊断要点: 1.急性移植物抗宿主病:发病在移植后7-30天,有发热、食欲不振、腹泻、腹痛、呕吐和肝脏损害等。 皮肤上发生充血性弥漫性皮疹,有的可呈麻疹样或猩红热样,极少数表现为大疱性...
Related to graft-versus-host disease:cGVHD graft-ver·sus-host disease (grăft′vûr′səs-hōst′, -səz-) n. A condition in which cells from the transplanted tissue of a donor initiate an immunologic attack on the cells and tissue of the recipient. ...
Recent Examples on the Web Kitchin was dealing with a complication known as graft-versus-host disease, where the donor cells begin attacking the recipient’s organs and tissues. Vanessa Etienne, Peoplemag, 15 July 2024 Amelia did end up with a bout of graft-versus-host disease; cyclophosphamide...
host disease (lasting >3 months after transplantation). The most frequent manifestation is the involvement of the skin, which in many cases can progress to resemble the changes of SSc. Skin changes consistent witheosinophilic fasciitisalso have been reported.301Graft-versus-host disease can lead to...
Thehost-versus-graft reactionoccurs when a graft or transplant (skin, heart, or kidney) is placed in a normal individual and the host's circulating immune cells react against the foreign tissue, causing graft or transplanted tissue destruction. Ingraft-versus-host disease(GVHD) the reverse happen...
these T cells recognize the recipient as 'non-self' and employ a wide range of immune mechanisms to attack recipient tissues in a process known as graft-versus-host disease (GVHD). The full therapeutic potential of allogeneic haematopoietic SCT will not be realized until approaches to minimize ...
Chronic graft versus host disease (cGVHD) can be defined as a chronic multisystemic immune deviation disease, which is accompanied by the absence of an adequate immune tolerance of donor-derived immune effector cells against the recipient's tissues and cells after the engraftment of the allogeneic ...
Find information on graft-versus-host disease (GVHD), including the types, managing GVHD, your transplant journey, community support, and resources.