Grb10 Deletion Enhances Muscle Cell Proliferation, Differentiation and GLUT4 Plasma Membrane Translocation. J. Cell. Physiol 2014; 229: 1753-1764.Mokbel N, Hoffman NJ, Girgis CM, Small L, Turner N, Daly RJ, et al. Grb10 deletion enhances muscle cell proliferation, differentiation and GLUT4...
These data demonstrate an important role for Grb10 as a link between muscle growth and metabolism with therapeutic implications for diseases, such as muscle wasting and type 2 diabetes. 展开 关键词: primary myoblasts proliferation growth factors signal transduction ...
In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated...
The stimulation of glucose uptake by insulin in muscle and adipose tissue requires translocation of the GLUT4 glucose transporter protein from intracellular storage sites to the cell surface(1-6). Although the cellular dynamics of GLUT4 vesicle trafficking are well described, the sig...
Structural components of the lipid raft microdomains; Characteristics of plasma membrane invaginations; Function of insulin in glucose uptake in striated muscle and adipose tissue.WatsonRobert T.ShigematsuSatoshiMoraSilviaShian-Huey ChiangKanzakiMakoto
In fat and skeletal muscle cells, insulin-responsive vesicles, or IRVs, deliver glucose transporter Glut4 and several associated proteins to the plasma membrane in response to hormonal stimulation. Although the protein composition of the IRVs is well studied, the mechanism of their formation is ...
Insulin increases glucose transport in fat and muscle cells by stimulating the exocytosis of specialized vesicles containing the glucose transporter GLUT4. This process, which is referred to as GLUT4 translocation, increases the amount of GLUT4 at the cell surface.Sano, HiroyukiPeck, Grantley R....
The INS-1 cell line was used to measure the amount of insulin secretion in the culture medium, while the HSkMC cell line was applied to analyze the amount of glucose uptake and GLUT4, AMP and Akt gene expression. Also, streptozotocin-induced diabetic rats were used to assess plasma glucose...
Non-muscle myosin II (NMII) proteins are vital cytoskeletal components that are ubiquitously expressed in a variety of cell types. The three NMII mammalian paralogs (A- C), encoded by the MYH9, MYH10 and MYH14 genes, respectively, differ in their expression profiles, and play both unique ...
Cell Metab 13: 68-79.Chen S, Wasserman DH, Mackintosh C and Sakamoto K. Mice with AS160/TBC1D4- 472 Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered 473 GLUT4 trafficking. Cell Metab 13: 68-79, 2011....