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专利名称：GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE AND METHOD FOR SELECTING INHIBITORS THEREOF 发明人：NAISMITH, James,BLANKENFELDT, Wulf 申请号：GB2001003152 申请日：20010713 公开号：WO02/006509P1 公开日：20020124 专利内容由知识产权出版社提供 摘要：There is provided a method of obtaining selecting ...
In this study, we describe the direct synthesis of uridine 5-diphosphate galactose (UDP-Gal) by a wild-type bacterial thymidylyltransferase (RmlA), which is used to synthesize thymidine 5-diphosphate glucose (TDP-glucose) in nature. By using magnesium (Mg2+) as a cofactor and a reaction ...
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专利名称：Glucose-1-phosphate thymidylyltransferase and method for selecting inhibitors thereof 发明人：JAMES NAISMITH,WULF BLANKENFELDT 申请号：AU7080701 申请日：20010713 公开号：AU7080701A 公开日：20020130 专利内容由知识产权出版社提供 摘要：There is provided a method of obtaining selecting agents ...
专利名称：GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE AND METHOD FOR SELECTING INHIBITORS THEREOF 发明人：NAISMITH, James,BLANKENFELDT, Wulf 申请号：EP01949689.2 申请日：20010713 公开号：EP1301621A2 公开日：20030416 专利内容由知识产权出版社提供 摘要：There is provided a method of obtaining selecting ...
There is provided a method of obtaining selecting agents which inhibit the enzyme glucose-1-phosphate thymidylyltransferase (Rm1A) based upon analysis of a model of the active and regulatory site (s) of Rm1A and interaction therewith by a potential inhibitory agent. The invention is based upon...
Glucose-1-phosphate thymidylyltransferase is the first enzyme in the biosynthesis of dTDP- l -rhamnose, the precursor of l -rhamnose, an essential componen... S Zuccotti,D Zanardi,C Rosano,... - 《Journal of Molecular Biology》 被引量: 218发表: 2001年 Genetic analysis of the dTDP-rhamno...
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