Ebola is an inexorable, negative-sense, single-strand, non-segmented RNA virus which rapidly develops alterations through error-prone replication and is known to be one of the most fatal diseases in humans. A member of Filoviridae, under the genus Ebolavirus, has found to be a cataclysmic and...
4 outbreak in Zaire Ebolavirus genome sequencing data for one sample from 2014 outbreak in ZaireEbolavirus genome sequencing data for one sample from 2014 outbreak in Zairedoi:10.6084/M9.FIGSHARE.3114454.V1Piccolo Stephen
The aim of this study was to produce cell-penetrable human single-chain antibodies (transbodies) that are able to interfere with the activities of interferon inhibitory domain (IID) of the VP35 protein, a multifunctional virulence factor of Ebola virus (EBOV). We speculated that effective VP35...
The nucleocapsid then interacts with the viral matrix protein, leading to specific packaging of the nucleocapsid into the virion. A mammalian two-hybrid assay and confocal microscopy were used to demonstrate that Ebola virus VP35 and VP40 interact and colocalize in transfected cells. VP35 was ...
Infection with Lassa virus (LASV) can cause Lassa fever, a haemorrhagic illness with an estimated fatality rate of 29.7%, but causes no or mild symptoms in many individuals. Here, to investigate whether human genetic variation underlies the heterogeneity of LASV infection, we carried out genome...
Ebola virus causes devastating hemorrhagic fever outbreaks for which no approved therapeutic exists. The viral nucleocapsid, which is minimally composed of the proteins NP, VP35, and VP24, represents an attractive target for drug development; however, the molecular determinants that govern the interacti...
The relevance of these findings to actual viral replication should be clarified in the future. This is a preview of subscription content, log in via an institution to check access. Similar content being viewed by others Non-coding regions of the Ebola virus genome contain indispensable ...
The Ebola Virus VP35 Protein Inhibits Activation of Interferon Regulatory Factor 3. We now show that VP35 inhibits virus infection-induced transcriptional activation of IFN regulatory factor 3 (IRF-3)-responsive mammalian promoters and that... Basler,F Christopher,Mikulasova,... - 《Journal of ...
Ebola virus Carbamoyl phosphate synthetase 2 aspartate transcarbamylase and dihydroorotase De novo pyrimidine synthesis Dihydroorotate dehydrogenase Host factor Teriflunomide siRNA screen Non-segmented negative-sense RNA viruses NNSV; 66.Human genetic variants and age are the strongest predictors of humoral im...
the VP35 protein of Ebola virus (EBOV) interacts with IKKε and TBK1 during the early phase of viral infection; this physical interaction with IKKε further prevents the interaction of IKKε with IRF3, IRF7, and MAVS214. Similarly, lymphocytic choriomeningitis virus (LCMV) NP binds to the ...