1. We present CisGenome, a software system for analyzing genome-wide chromatin immunoprecipitation data. 我们提出了一个软件系统来分析基因组范围的ChIP数据,叫做CisGenome。 2. The main results obtained were as follow:1 The DN A polymorphism of genome A and genome B between common wheat and wild em...
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One major expectation from the transcriptome in humans is to characterize the biological basis of associations identified by genome-wide association studies. So far, few cis expression quantitative trait loci (eQTLs) have been reliably related to disease susceptibility. Trans-regulating mechanisms may pla...
transgenome英音: [træns'dʒi:nəum] 美音: [træns'dʒi:nəum] 转移基因组相关短语 melt release system (转移印花用语) 熔释体系 genuine pleiotropism (基因) 真多效性 morgan (基因交换单位) 摩 polar wandering (地极游移) 地极迁移 Wagner's theory (移行学说) 瓦格纳氏学说 移植外...
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Potent trans inhibition was also observed following cotransfection of the S genome and a plasmid encoding the larger delta antigen. Mutational analysis indicated that the inhibitory activity was not a simple function of the large delta antigen reading frame's extra length. Implications for the viral...
目前,PE在各种应用中显示出巨大的潜力,包括小片段indels、单核苷酸转换和大片段缺失,但还不能实现片段扩增。该研究开发了一种新颖的PE策略,即TD-PE,通过使用一对方向相反的in-trans pegRNA,在哺乳动物基因组中产生大型DNA片段的串联重复。这些pegRNA诱导从目标区域单链DNA外向延伸,并且延伸的单链DNA及其边界序列被...
2023年6月9日,四川大学姚少华团队在Genome Research在线发表题为“Targeted, programmable, and precise tandem duplication in the mammalian genome”的研究论文,开发了一种基因扩增编辑的策略(TD-PE),实现了在哺乳动物基因组中定点、可编程和精确的串联扩增。在这种策略中,每个目标串联重复设计一对先导编辑引导RNA(peg...
Also, we performed a transethnic meta-analysis of our cohort with a previous GWAS on T2D in multi-ancestry individuals (180,834 T2D cases and 1,159,055 controls). One locus in DYNC2H1 gene reached genome-wide significance in the meta-analysis. Assessing polygenic risk scores derived from ...
4DTV( four-fold synonymous (degenerative) third-codon transversion) 表示4D位点(fourfold degenerate site)上发生颠换(嘌呤突变为嘧啶或者嘧啶突变为嘌呤)的位点替换率。什么事4D位点呢? 一个遗传密码子通常由三个核苷酸构成,从左到右依次为第一个位点、第二个位点、第三个位点。如果密码子的某个位点上无论是...