Morgan's development of the initial genetic linkage map in Drosophila (Rubin & Lewis, 2000). Briefly, genetic mapping involves utilizing recombination and traceable genetic markers to identify regions in the genome that contain genetic elements of interest (Fig. 4.1). Historically, these approaches ...
After refinement, the median resolution of autosomal recombination events is 26.9 kb, with 28.6% of events resolved to within 10 kb, compared to 34.7 kb resolution and 19.5% of events within 10 kb in the unrefined map (Fig. 1a). The female and male refined maps have similar ...
Heatmap of pair-wise cross-datasets conditional analyses (step 3) for cell types retained from the step 2. Cell types are labeled using their common name with additional information in parentheses (which is needed when referring back to the label from the original study). The index of the ...
E.S. Lander The new genomics: global views of biology Science, 274 (1996), pp. 536-539 View in ScopusGoogle Scholar Lander and Botstein, 1987 E.S. Lander, D. Botstein Homozygosity mapping: a way to map human recessive traits with the DNA of inbred children Science, 236 (1987), pp...
In biology, mutations are changes to the nucleotide sequence of the genetic material of an organism. Mutations can be caused by copying errors in the genetic material during cell division, by exposure to ultraviolet or ionizing radiation, chemical mutagens, or viruses, or can be induced by the ...
The genetic architecture of common diseases is central to the scientific and clinical goals of human genetics because it directly impacts biology, disease screening, diagnosis, prognosis and treatment. Genetic architecture is currently assessed by exploiting the differences in types of genetic variants asc...
Forearm fracture definition For the discovery meta-analysis using the UFO, HUNT, UK Biobank, EstBB and FinnGen cohorts, we included forearm fractures derived from high quality national registers based on medical and/or radiological reports classified according to International Classification of Diseases ...
Combining the previous linkage map [17] and phenotypic data of the RIL9 population, the QTL mapping on DFF was performed using the composite interval mapping (CIM) function of WinQTL Cartographer Version 2.5 [18,19]. The QTLs were named according to their chromosome location, trait name and ...
A genetic relationship between phosphorus efficiency and photosynthetic traits in soybean as revealed by QTL analysis using a high-density genetic map. Front. Plant Sci. 2016, 7, 924. [Google Scholar] [CrossRef] [Green Version] Kochian, L.V.; Hoekenga, O.A.; Pineros, M.A. How do ...
InDels have also been widely applied for genotyping, genetic diversity analysis, QTLs mapping, map-based cloning, and even marker-assisted selections in Arabidopsis, rice, wheat, turnip, sunflower, citrus, and Atlantic salmon [35–43]. In this study, we developed and characterized 349 EST-SSR ...