protein supplementsfertilitygeneThe study was conducted to investigate the effect of different levels of protein supplements on fertility and assess the fertility gene ( BMP15 and GDP9 ) in sheep of Bangladesh. Thirty six ewes fed two protein level (Treatment 1, T1 and treatment 2, T2) and ...
To confirm the regula- tory role of GDF9 on P4HA2, hGCs were incubated with 200ng/ml recombinant mature GDF9 (HY-P72425, MCE, USA) with or without 10μM SB431542 ( HY-10431, MCE, USA), an inhibitor of GDF9 receptor ALK5, for 24-48 hour and then RNA and protein were ...
Bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) are oocyte-specific growth factors that appear to play key roles in granulosa cell development and fertility in most mammalian species. We have evaluated the role(s) of these paracrine factors in the development and...
constructed.TheresultsshowedthattheORFofGDF9was1362bpwhichencoded452aminoacids.Thesheepproteinof LHI3was51773.63Dinmolecularweight.TheGDF9playedanimportantroleinsignaltransducerinmembrane. Keywords:Sheep;GrowthDiferentiationFactor9Gene;Bioinformatiesanalysis ...
the GDF 5/6/7 of TGF-β family member can also play a biological role through smad 1/5/8 albumen, like the different function of GDF-5 in the structural and functional maintenance of intervertebral disk, GDF-6 in the promotion of cartilage expression and GDF-7 in mammary cancer [21-23...
We performed a computational biology analysis to determine the role of GFD9 in mammalian ovarian function. We constructed a three-dimensional model of GDF9 using I-TASSER and human GDF9 protein sequences obtained from UniProt. We also analyzed GDF9 gene...
The oocyte secretes growth factors which directly induce follicular development by a complex paracrine signalling process, and the transforming growth factor尾 (TGF-尾) superfamily has a pivotal role in this process. The bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9...
A novelGDF9variant is herein reported to consolidate the role ofGDF9in ovarian function and female fertility.#A 38-year-old female was referred for the investigation of secondary amenorrhea. Eventually, she was referred for genetic evaluation whereby conventional karyotyping and Fragile-X molecular ...
family members and was subjected to positive selection in the mammalian clade. Selected sites under the positive selection are of remarkable significance for the particular functioning of the protein and consequently for female fertility.AhmadHafiz Ishfaq...
(TGF- 尾) super family: growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) originates from oocytes are played a very important role in determining follicle growth and these two genes drastically altered fertility and ovulatory rate and early folliculogenesis in humans....