Fungi are pathogenic to humans and cause a variety of diseases in normal and immunocompromised hosts. Fungi can exist as filamentous/mould or yeast form, both forms are able to cause infections in human host. Dimorphic fungi, that is, Histoplasma capsulatum also exist and can grow as a ...
human fungal infectionsmacrophagesSummary The current working paradigm in fungal immunity is that adaptive and innate components of the immune system collaboratively generate a broad range of immune responses to limit the spread of and clear fungal pathogens. The majority of opportunistic fungal infections...
Hidden Killers Human Fungal Infections隐性杀手:人类真菌感染.pdf,Hidden Killers: Human Fungal Infections Gordon D. Brown et al. Sci Transl Med 4, 165rv13 (2012); DOI: 10.1126/scitranslmed.3004404 A complete electronic version of this article and other se
Multicenter clinical evaluation of the (1–>3) beta-d-glucan assay as an aid to diagnosis of fungal infections in humans Clin Infect Dis, 41 (2005), pp. 654-659 CrossrefView in ScopusGoogle Scholar 37 A.M. Tortorano, M.C. Esposto, A. Prigitano, et al. Cross-reactivity of Fusariu...
Unlike viral, bacterial and parasitic infections, fungal infections in humans are usually only superficial in healthy individuals, but can become invasive and pose serious risks to immunosuppressed individuals. Although their global impact is less than that of other infectious disease...
Immunopathogenesis of CNS fungal infections in humans is not completely understood. The exploration of the genomic sequence of most fungal pathogens can help better understand pathogenesis, virulence and immune response of host defense against these pathogens. Further studies in these areas will advance ...
In the past few decades, a lethal disease has decimated populations of frogs and other amphibians worldwide, even driving some species to extinction. Yet other amphibians resisted the epidemic. Based on previous research, scientists at the INDICASAT AIP,
This review discusses the inclusion of sex and gender variables in studies of fungal infections in humans at the pathogen, host, and antifungal trial levels. The mating type of some fungi, or perhaps more likely the absence of the other, appears to be associated with some infections. Sexual ...
Despite the substantial global burden of human fungal infections, there are no approved fungal vaccines to protect at risk individuals. Here, we review the progress that has been made and the challenges that lie ahead in the quest towards efficacious fungal vaccines. In mouse studies, protection ...
controlled type I IFN response, as high amounts of IFN-β inhibited MMP14 through the ISGBST2and increased pathogenic TH17 polarization. Thus, dectin-1 regulated type I IFN expression to allow the TGF-β-mediated development of non-pathogenic TH17 responses during fungal infections in humans. ...