Janus kinase / signal transducer and activator of transcription (JAK/STAT) is a vital signaling pathway that regulates cellular activity and inflammatory response, closely correlated with multiple diseases development and advances. Currently, the potential effect of JAK/STAT on C. perfringens beta2 (...
To investigate this poorly understood phenomenon, we adopted an in-vitro model of endotoxin tolerance utilising primary human CD14 + monocytes to focus on the effect of impairment on IκKα/β, a critical part of the NFκB pathway. Impaired monocytes had decreased IκKα mRNA and protein...
The complex STATes of astrocyte reactivity: how are they controlled by the JAK-STAT3 pathway? Neuroscience 330, 205–218 (2016). Article CAS PubMed Google Scholar Zhong, Z., Wen, Z. & Darnell, J. E. Stat3 and Stat4: members of the family of signal transducers and activators of ...
Bogdan C: The function of type I interferons in antimicrobial immunity. Curr Opin Immunol 2000, 12:419 - 424Bogdan C: The function of type I ... C Bogdan 被引量: 0发表: 2000年 The JAK-STAT pathway at twenty. the tyrosine kinases TYK2 and JAK1 and the transcription factors STAT1, STA...
PPAR-γ inhibits inflammation by blocking JAK-STAT, activa- tor protein-1 (AP-1), NF-κB, nuclear factor of activated T cells (NFAT) signaling pathways. It ameliorates sclerosis by inhibiting foam cell differentiating, inflammation and cell proliferation. It maintains glucose homeostasis by PI3K,...
(JAK/STAT) pathway [103,104,106]. Tumor necrosis factor alpha (TNFα) also activatesPMLtranscription by promoting STAT1-dependent transactivation of thePMLpromoter [107,108]. Moreover, interleukin 6 (IL-6) enhancesPMLtranscription via NF-κB and JAK-STAT pathways [109]. In summary,PML...
that Hippo pathway activity limits JAK/STAT pathway activity in the soma, as Stat92E is a readout of JAK/STAT activity [37]. In addition, decreasing the activity of Dome, a JAK/STAT receptor, in the soma significantly decreases TFC number while double knockdown ofdomeandhpocompletely suppress...
gondii infection could regulate the expression of Arg-1 and IL-10 via the SHP-2/STAT6 pathway, resulting in the dysfunction of dMDSCs, which might contribute to adverse outcomes during pregnancy by T. gondii infection. Graphical abstract
The H4R is highly expressed on eosinophils from AD patients and IL‐4 upregulates expression and function via the JAK/STAT pathwayatopic dermatitiseosinophilsH4RhistamineIL‐31doi:10.1111/all.14599John Wiley & Sons, LtdAllergy
JAK/STAT Pathway Plays a Critical Role in the Proinflammatory Gene Expression and Apoptosis of RAW264.7 Cells Induced by Trichothecenes as DON and T-2 Toxin Deoxynivalenol (DON) and T-2 toxin commonly affect cells of the immune system and cause inflammation and apoptosis. Janus kinase/signal tra...