Function of CFTR protein: ion transport. In: Cystic Fibrosis in the 21st Century, ed. Bush A, Alton EWFW, Davies JC, Griesenbach U & Jaffe A, pp. 38-44. Karger, Basel.Chen JH,Cai Z,Li H,Sheppard DN.Function of CFTR protein: ion transport. Cystic Fibrosis in the 21st Century ....
1C). We next investigated the Forskolin induction dose-dependency in a homozygous G542X PDO, recognizing that the Forskolin concentration required for induction could be dependent on the amount of CFTR protein present (Fig. 1D). ELX-02 mediated activity was observed at the lowest Forskolin ...
The data presented also show that RTX0001, the Company’s mRNA replacement agent for CF, restores CFTR function in the gold-standard CF patient-derived hBE cell model. The mRNA payload was successfully nebulized and...
Protein ingestion (especially arginine), β-adrenergic stimulation, vigorous exercise, fasting and cholecystokinin secreted by duodenal cells also increase glucagon secretion. The main function of glucagon is to promote utilization of stored nutrients and its action principally involves the liver. Glucagon ...
We previously reported that VX-770, when used in combination with a second potentiator identified by high-throughput screening, increased chloride channel function of N1303K-CFTR and the truncated W1282X-CFTR protein product by ~8-fold compared with VX-770 alone1,10. This combination-potentiator...
Function of CFTR; Materials and met... O Baldursson,HA Berger,MJ Welsh,... 被引量: 0发表: 2019年 Stimulation of Elk1 Transcriptional Activity by Mitogen-activated Protein Kinases Is Negatively Regulated by Protein Phosphatase 2B (Calcineurin) Elk1 at phosphoserine 383, a site whose ...
et al. Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein. Nat Biotechnol. 30, 876–882 (2012). Article PubMed PubMed Central CAS Google Scholar Xia, M. et al. Compound cytotoxicity profiling using quantitative high-throughput ...
protein called [...] chinese.eurekalert.org chinese.eurekalert.org 许多吸烟者患慢性阻塞性肺病,这是一组类似于囊性纤维化的病症,它是由肺的气道中的一种称为囊性纤维化跨膜电导调节因子(CFTR)的离子输运蛋白的功能缺陷导致的。 chinese.eurekalert.org ...
SMG1-ASO mediated NMD inhibition upregulates the RNA, protein and surface-localized protein expression of the truncated W1282X gene product. Additionally, these ASOs increase the CFTR chloride channel function in cells homozygous for the W1282X mutation. Our approach suggests a new therapeutic ...
AnxA2 Annexin A2 protein anxA2 annexin A2 mRNA CRM1 chromosome region maintenance-1/exportin-1 CFTR cystic fibrosis transmembrane conductance regulator protein EGF epithelial growth factor HUVEC human umbilical vein endothelial cells LmB Leptomycin B MDCK Madin-Darby canine kidney cells NES nuclear export...