The development of the cortex is a delicate balance between proliferation, differentiation, and migration of neural progenitors (NPs). Throughout developmental process, various cellular mechanisms ensure that NPs differentiate into the correct cell subtypes, migrate to their correct regions, and form the...
High-altitude cerebral edema (HACE), which is characterized by headache, ataxia, fatigue and altered mental status, is a severe form of high-altitude illness that typically occurs after people rapidly ascend to 2500 m or more [1]. It can lead to coma and death without timely diagnosis or ...
As bypass signaling is a common form of resistance to kinase inhibitors, we sought to identify potential kinases that are activated in ASK120067-resistant cells. We performed a human phospho-RTK array and compared the differential expression of 71 tyrosine kinases in parental and resistant NCI-H197...
Jin-Gui-Shen-Qi Wan (JGSQ) has been used in China for thousands of years to treat various ailments, including frequent urination, blurred vision, and soreness in the waist and knees. It has traditional therapeutic advantages in improving eye diseases. Cl
TREM2 is also present in a soluble form (sTREM2), and its CSF levels fluctuate as a function of AD progression. Analysis of stroke and AD mouse models revealed that sTREM2 proteins bind to neurons, which suggests sTREM2 may act in a non-cell autonomous manner to influence neuronal ...
Thomas DM, Segaloff DL: Hormone-binding properties and glycosylation pattern of a recombinant form of the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor expressed in mammalian cells. Endocrinology. 1994, 135: 1902-1912. CAS PubMed Google Scholar Roche PC, Ryan RJ: ...
Pluripotent stem cells differentiate to form every complex tissue structure of multicellular life. The progression of pluripotent stem cells to a differentiated cell state is mediated by epigenetic modification of DNA and histone proteins, including methylation or acetylation of the lysine 27 position on...
COs are an advanced form of in vitro models that are capable of resembling the human brain in the CO formation process, cellular or structural composition, and intercellular connections. COs have great potential to create qualified models of CNS diseases, including AD, and provide a platform to ...
The therapeutic targets of OA were converted from “gene name” to “UniProtKB” form using the UniProt database (https://www.uniprot.org) [36]. Next, the KEGG IDs were obtained, and the target’s pathway information was matched using KEGG Mapper (https://www.genome.jp/kegg/mapper/). ...
Although the advances in surgeries, chemotherapy and targeted treatment approaches for breast cancer have improved overall survival rates in recent years, the therapeutic modalities are still limited for aggressive breast cancers such as the triple-negative form [2]. The rapidly growing field of cancer...