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Aβ is generated by the normal cleavage of the amyloid-beta precursor protein (APP), which then can oligomerize and form extracellular deposits [9, 10]. Some mutations in the APP gene cause a familial early-onset form of AD through modification of APP cleavage resulting in an increase in A...
Studies have also focused on whether PSM is associated with individuals’ sector choices, and whether PSM could form the basis of recruiting candidates for public organisations [7, 8]. A number of studies have established that measures of PSM among public servants are greater than for those ...
Eventually, this population model could form the basis to individually predict tumor exposure and treatment response using Bayesian forecasting (similar as applied in a therapeutic drug monitoring approach [70]). Baseline PSA levels combined with observed uptake in tumors and all prior known patient ...
Dinoflagellate genomes form topologically associated domains (TADs; Fig.2C), a feature widely found in eukaryotic genomes [28,29]. TAD is a genomic region where DNA sequences within the same TAD interact with each other more frequently than with sequences outside of it [38]. Between the two...
In addition, circRNAs can also interact with RNA-binding proteins (RBPs) to form specific complexes that subsequently mediate the function of associated proteins [18]. Increasing evidence indicates that circRNAs could also exert their functions through regulating transcription and encoding peptide [19, ...
of T24 cells after incubation with NSs-RB and NSs-RB-F/cRGD (50 μg mL−1). Data in (e,g,i, andk) were presented as mean values ± SEM. ThePvalues in (g) were calculated by one-way ANOVA and multiple-comparison test. ThePvalues in (iandk) were calculated by paired...
Phosphorus (P) is an essential nutrient for energy metabolism, genetic materials, and cell structures of all biota [1]. Unlike nitrogen (N), which has the volatile form of N (e.g., N2, N2O), the atmosphere does not supply soluble P [2]. Therefore, P is the second most limiting nut...
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The dependence of t2 on k p ' can be explained by two factors: first, the fact that the relative error in this rate assumed for our sensitivity analysis (35%) is larger than that obtained for k a ' in the fit, and second, due to the functional form of t2. Equation 48 shows ...