Trial registration This study was registered with the Japan Registry of Clinical Trials (jRCT; registry number: jRCTs021230005).Peer Review reports Background Advanced pancreatic cancer is one of the leading causes of cancer-related death [1]. The 5-year survival rate of advanced pancreatic cancer...
These contexts relate to how the reduction is implemented (form), the extent and the level of implementation, what other changes took place (such as some organizations not reducing the workload, resulting in increased work intensity) (e.g., [37]), the work conditions and wage compensation, ...
HTT polyglutamine lengths are expressed as HTT CAG(n)-length plus two (CAA, CAG) alleles; lengths below 36 repeats correspond to wild-type HTT, whilst those above correspond to the mutant form of the protein. For the iPSCs, briefly, biopsies were performed in accordance with the ...
1c). AT1 cells are flattened and squamous, and they cover more than 95% of the gas exchange surface of the alveoli and are closely associated with the surrounding endothelial capillary plexus to form the thin gas diffusion surface. AT2 cells are cuboidal and secret pulmonary surfactant, which ...
Schematic of adult human and mouse lung stem cell-derived organoids. Human and mouse airway basal cells form tracheosphere or bronchosphere when cultured in 3D Matrigel (Rock et al., 2009; Danahay et al., 2015). Human and mouse AEC2s form alveolosphere with or without the support of fe...
Forest fires represent a severe threat to Mediterranean ecosystems and are considered one of the major environmental and socioeconomic problems of the region. The project Plantando cara al fuego (PCF, Spain) is designed to transfer knowledge and to improve the training of new generations in forest...
reported that copper ions can directly bind to lipoylated tricarboxylic acid cycle (TCA) proteins to induce cell death, and this form of cell death is named cuproptosis [5]. Recently, some studies confirmed that the deficiency or overload of copper in the body is clearly associated with many...
The full form of the model is as follows: [Math Processing Error]log(μt)=intercept+cb(pollutantt;lag)+cb(tempt;lag)+cb(humidt;lag)+cb(raint;lag)+cb(ILI+Totalt;lag)+s(yeart)+s(weekt)+offsett+Autoregressiveterms where μt is the expected number of AOM admissions in a given week...
Microenvironment of brain metastases Blood‒brain barrier The BBB, from the lumen side of the brain capillaries to the side of the parenchyma, is composed of vascular endothelial cells (VECs), pericytes that envelop the endothelial cells and form a basal lamina, and the endfeet of astrocytes....
The functional response of a plant community to a wildfire can be used to study the response to the new environment and to the disturbance across taxa (Donato et al. 2009). Traits related to regeneration strategies (i.e., seed longevity, germination, growth form) and competition (i.e., ...