maintain the functional structure of FGL2, forming an essential immunoregulatory domain [21,62,63]. The three amino acids (362, 364, and 366) near the C-terminus constitute the Ca2+binding site. Adjacent to the Ca2+binding site, five amino acids (371, 374, 375, 384, and 385) form the...
Effects of HFD and SBJDD administration on spontaneously form colorectal adenomas model of Apcmin/+ mice. A Schematic of in vivo experimental procedure (ND: normal diet group, HFD: high-fat diet group, SBJDD: Shen-Bai-Jie-Du decoction group). B Body weight change. C Representative colorectal...
reported that silymarin supplementation changes the composition of gut microbiota and increases caecal concentrations of SCFAs in high-fat diet (HFD)-fed mice [72], which may be responsible for improving MASLD. The biotransformation of silymarin mediated by human gut microorganisms has been monitored ...
Along with other phagocytes, they form the initial line of defence by releasing proinflammatory cytokines, which contribute to the activation of the innate immune system and subsequent T- and B-cell responses [2]. Macrophages can be polarized to acquire different phenotypes based on various stimuli...
morifolium and probiotics combination (CP) on alleviating nonalcoholic fatty liver disease (NAFLD) and the dysregulation of glucose metabolism in high-fat diet (HFD)-fed mice. Methods The therapeutic effect of CP on metabolism was evaluated by liver histology and serum biochemical analysis, as well...
(T3), the active form of TH, binds to NR proteins and mediates effects on the systemic vasculature include relaxation of vascular smooth muscle, resulting in decreased arterial resistance and diastolic blood pressure [65]. In patients with hyperthyroidism, cardiac contractility and cardiac output are...
(iii) What factors lead to changes in metabolites, including the status of enzyme systems that control their synthesis and degradation, as well as the regulatory networks they form? (iv) Considering that cancer-immune interactions involve various cell subsets, how are these metabolites, pathways, ...
Simultaneously, autophagy serves as a form of self-degradation that not only functions as a downstream mechanism of miRNA but also governs its functionality [93]. Autophagy regulates miRNA biogenesis by degrading Dicer, thus controlling subsequent downstream events [94]. The atheroprotective factor miR...
The biological effects observed in the aforementioned PDNVs form the basis for their tissue protection and repair properties. However, some studies have only conducted a superficial assessment of the PDNVs' activity without delving into the specific underlying mechanisms. It remains unknown whether the...
High-fat diet (HFD).HFD induction can be given alone or together with single or multiple low doses of STZ to induce insulin resistance, diabetes, and complication. There were two types of variations of HFD, (a) high-fat diet alone or (b) high-fat diet with a combination of high-sucro...