Descriptive data and results from included studies were extracted using a study-specific form created and completed in Covidence software [26]. Data extraction was completed independently by the two researchers (K.M and C.M) that conducted the screening process. Extracted data was compared in Covid...
Besides, recent studies have explored the mechanisms of post-translational modifications on the regulation of PD-L1 expression. For instance, PD-L1 glycosylation triggered by B3GNT3 plays an important role in its expression; deglycosylation increases the anti-PD-L1 antibody binding affinity, leading ...
A significant proportion of mammalian genomes, between 11 and 33%, has been classed as potential enhancers based on genomic associations with markers of enhancer activity across cell and tissue types. This “enhancer real estate” is significantly larger than the 2% of the genome that comprises of...
These core structures can undergo further extension and branching to form more highly complex O-glycans [13]. Mucin type O-linked glycans are synthesized in the Golgi apparatus [14] in a stepwise and consensus motif-independent manner. A family of UDP-GalNAc polypeptide:N-acetyl-α-galactos...
The second stage of biotin synthesis is a highly conserved process starting from the precursor pimelate moiety, sequentially catalyzed by the enzymes BioF/BioA/BioD/BioB. The pimelate moiety contributes two carbon atoms to form its rings and five carbon atoms to from the valeric acid side ...
Disturbances in N-linked glycosylation affect the stability of the cadherin-catenin complex and modulate tumor cell‒cell interactions. In human fibrosarcoma, upregulation of GnT-V expression in tumor cells alters N-cadherin function, leading to loss of cell‒cell adhesion and cell invasion [31]...
WLC was funded by the Ministry of Science and Technology of Taiwan (grant 108-2628-E-006-002-MY3), the Ministry of Education of Taiwan, Global Networking Talent 3.0 Plan (GNT3.0), and the Medical Device Innovation Center, National Cheng Kung University. The funders did not participate in th...
In Europe, sarcoglycanopathies are often considered the second most frequent form, with prevalence rates of 15–18.1% in Italy and 27% in the Netherlands. In the Brazilian population, sarcoglycanopathies are the most frequent cause of severe autosomal recessive LGMD (68%) and childhood-onset ...
Initial contact will be made in the form of an email, newsletter or flyer outlining the intent of the research and information on how to participate. Potential participants who are interested in taking part will be required to contact the research team if they would like to participate, ...
[56]. Endocytosis, a form of active transport in animals and plants, brings substances into the cell by surrounding them with a cell membrane, then budding off inside the cell to form a vesicle containing the ingested material. In plants, salt stress induces rapid clathrin-mediated endocytosis ...