The latter impairment is the most serious form of DNA damage [135]. A disfigured genome is the stimulus that initiates DNA damage response (DDR) processes [136,137]. These consist of a series of complex events that heal the DNA lesions. When the damage is highly deleterious, however, it ...
Two types of pneumococcal vaccines both targeting capsular polysaccharides are currently licensed: (a) the 23-valent pneumococcal polysaccharide-based vaccine (PPV-23) and (b) the 7-, 10-, and 13-valent pneumococcal conjugate vaccines (PCV-7, -10, -13). PPV-23 is poorly immunogenic in ...