Overactive bladder (OAB) presents a high prevalence of 16–18% worldwide. The pathophysiology of OAB is still poorly understood while effective therapy or countermeasure are very limited. On the other hand, medicinal plants and herbal remedies have been
ECFC treatment did not have a significant effect on body weight, brain weight, or B/BW ratio.Fig. 2Data are mean ± SEM for body weight, brain weight, and brain/body weight (B/BW) ratios in AGA (Black; n = 7), FGR (Grey; n = 5), AGA + ECFC (Black ...
Thus, the clarification of the dynamics of OPN metabolism in distinct infectious diseases is essential for understanding the immune system and contributing to the treatment of a wide range of inflammatory diseases. 4. OPN in Infectious Diseases 4.1. ATL ATL is caused by human retroviruses, human ...
Initial denaturation at 95°C for 10 min was followed by 1 min cycling intervals at 60°C using RotorGene RG-3000 cycler (Corbett-Research, Sydney, Australia). Differential transcription was calculated by the ΔΔCT method [55].Abbreviations DSD: disorders of sex development CAH: congenital ...
year in which we transformed Pharming into a multi-product, commercial rare disease biopharmaceutical company. We grew RUCONEST® revenues by 10% in 2023. This demonstrates the continued need for, and importance of, RUCONEST® as a trusted cornerstone of trea...
-related patents account for the largest proportion of pharmaceutical formulations, also corresponding to the first monkeypox-related patent, which indicates that in the field of the monkeypox virus, enterprises and academic circles focus on the research and development (R&D) of drugs for treatment....
During the 24-h study period, the body temperature of CLP mice was significantly lower than that of sham mice, after treatment with MSCs; the body temperature of the mice can be slightly increased. In addition, there was no significant difference in body temperature between MSCs and MSC-TGF-...
treatment regimens for SARS-CoV-2 infections and COVID-19 respectively. SARS-CoV-2 variants with public health concerns are continually reported worldwide. The emergence of these variants not only affects viral transmission and virulence, but also hinders vaccine development and production. Tracking ...
Notably, perhexiline has been approved for angina treatment in Australia and Asia, therefore it could be translated quite safely into anti-tumor trials. While clinical trials for anti-tumor treatment have not yet been conducted with CPT inhibitors like etomoxir, perhexiline, and ST1326, ...
Next-generation humanised mouse models and single-cell RNA sequencing (scRNAseq) approaches enable in-depth studies into human immune cell biology. Here we used NSG-SGM3 mice engrafted with human umbilical cord haematopoietic stem cells to investigate ho