An extension of the ABO system to include an arbitrary number of codominant alleles has been made, and such a multiple allele locus has been called the ABO-like system (Yasuda and Kimura, 1968). Obviously, one of the most important examples in this genetic system is the HLA polymorphisms. ...
To systematically evaluate the pathogenic potential of presumably pathogenic variants with AFs higher than the thresholds defined for the general population, we applied the 2015 ACMG guidelines for variant classification with InterVar, one of the most commonly used bioinformatics tools for clinical interpret...
When using a Punnett square to predict offspring ratios, we assume that a. each gamete contains one allele of each gene. b. the gametes have all possible combinations of alleles. c. male and female gametes combine at random. d. All of these are correct. ...
If you'd like to calculate the phenotype/genotype frequency of certain alleles or learn how to calculate allele frequency in the next generation, try: The Punnett square calculator for one trait; The dihybrid Punnett square for two traits; or The trihybrid cross calculator for three traits. And...
alleles is observed (D’ = 0.929, r2= 0.884). Conclusion: The results from the present study show that bothCYP2C9pVNTRandCYP2C9*3are in a high LD, which could help to better understand the lower metabolic activity exhibited byCYP2C9*3allele carriers. These data might be relevant for...