Discussion PC has been considered as chemo-refractory disease for a long time. Patients with metastatic PC that progresses after 5FU-based chemotherapy have had a little opportun- ity to receive second-line chemotherapy, mainly because of poor PS prohibiting further therapy. Gemcitabine first- line...
19-21 In approximately one-third of patients, cfDNA levels clearly increased by greater than 20% after the first treatment cycle (2-3 weeks). Early cfDNA increase (>20%) was a strong predictor of both shorter PFS and OS in the cohort (Figure 3B; eFigure 6 in Supplement 3). Patients ...
dominant Results Table 2 Demographic and clinical characteristics of patients. Full size table Table 3 Tumor characteristics. Full size table After a median follow-up of 74.5 months (75.5 in women and 73.7 in men,p = 0.9260), 152 (29.7%) patients experienced grade ≥3 hematological ...
The first thermotherapy treatment was FOLFOX6; the second thermotherapy treatment was FOLFIRI;14-day cycle, two times was one course; alternated use of the two chemotherapies, clinical efficacy were assessed after each 2 chemotherapies by rechecking, the patients received 4~6 thermotherapy treatment...
Pre- and postdose 5-ml blood samples were collected at prespecified time points in cycle 1 during and after infusions. Symptoms or side-effects that were associated with rapid infusion of high-osmolarity solution or treatment-related adverse events that were possibly attributed to high-dose AA ...
Several mechanisms could be involved in the increase of checkpoint receptor expression after chemotherapies. In a recent study, Samanta et al. reported a HIF-dependent mechanism for an increase in PD-L1 and CD47 expression after treatment with chemotherapeutic agents11. Furthermore, ICD inducer ...
Consent for publication The informed consent form sated that the result would publish after completed the study. Japanese regulation. The consent of the family is not be demanded at article publication by the ethic guideline in Japan. Competing interests Outside the submitted work, Keisuke Miwa ...