帕尼单抗(Panitumumab,商品名Vectibix)是一种完全人源化的单克隆抗体,它通过特异性结合表皮生长因子受体(EGFR),抑制其与配体的结合,进而阻断配体诱导的受体自磷酸化及相关激酶激活,从而抑制肿瘤细胞生长,诱导凋亡,并减少促炎细胞因子与血管生长因子产生。这一独特的作用机制,使得帕尼单抗成为结直肠癌治疗领域的重要药物。
编者按:根据发表在《临床肿瘤学杂志》(Journal of Clinical Oncology)上的PANDA试验数据,帕尼单抗(panitumumab)联合5-氟尿嘧啶/亚叶酸钙单药(5-FU/LV)或改良的FOLFOX(mFOLFOX)双药化疗均能有效治疗RAS/BRAF野生型转移性结直肠癌(mCRC)老...
在2017年9月~2021年9月期间,该研究于57个意大利研究中心招募了435名先前未经治疗且不可切除RAS和BRAF wt mCRC患者,受试者被随机1:1分配到改良FOLFOX/panitumumab(对照组)或mFOLFOXIRI/panitumumab(实验组)(最长12个周期),然后用氟尿嘧...
Panitumumab Plus FOLFOX for KRAS Wild-Type Metastatic Colorectal CancerMatthew Stenger
PARADIGM试验显示,在RAS野生型(WT)和左侧转移性结直肠病(mCRC)患者中,一线mFOLFOX6 + 帕尼单抗(panitumumab,PAN)对阵. 贝伐珠单抗(BEV)的中位总生存(OS)更长(分别为37.9个月对阵. 34.3个月;风险比[HR],0.82;P=0.031),右侧结肠病患者的OS与之相似(HR 1.09;Yoshino T, et al. ASCO 2023 LBA1)。我们通过...
PanitumumabFOLFOXFOLFOXIRIDoublets plus anti〦GFRs are the preferred upfront option for patients with left﹕ided RAS/BRAF wild‐type metastatic colorectal cancer (mCRC). Initial therapy with FOLFOXIRI‐bevacizumab is superior to doublets plus bevacizumab independently from primary tumor sidedness and RAS...
Immunohistochemical analysis revealed loss of PTEN expression in rectal cancer compared with liver metastases from sigmoid colon cancer, showing that the difference of mFOLFOX6 with panitumumab might be related to activation of the PI3K-AKT pathway. 展开 关键词: Panitumumab mFOLFOX6 Colorectal cancer...
Panitumumab plus mFOLFOX6 "represents good value for money" relative to bevacizumab plus mFOLFOX6, and can be considered cost effective for the first-line treatment of patients with wild-type RAS metastatic colorectal cancer, state researchers from France and the US. Their study was funded by ...
A similar study testing another anti-EGFR monoclonal antibody (Panitumumab) is currently ongoing in the United Kingdom (FOxTROT trial). The pilot stage of this randomised controlled trial on the first 150 included has been recently published. Nearly 90 % (85 of 95) of patients in this trial ...
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