fluorineHIVsubstitution reactionsIn recent times, fluorine aromatic and aliphatic substitution has become one of the key structural traits in modern pharmaceuticals. Many of the most successful drugs contain fluorine atoms, offering advances in the treatment of various diseases. In this Review by V.?A...
X.-L. Qiu, X. Yue, F.-L. Qing, Fluorine-containing chiral drugs, in: G.-Q. Lin, Q.-D. You, J.-F. Cheng (Eds.), Chiral Drugs, John Wiley & Sons, Inc., Hoboken, NJ, 2011, pp. 195-252.QIU XL, YUE X, QING FL, et al. Fluorine-containing chiral drugs[M]//LIN GQ,...
摘要: This article reviews current knowledge of the metabolism of drugs that contain fluorine. The strategic value of fluorine substitution in drug design is discussed in terms of chemical structure and basic concepts in drug metabolism and drug toxicity.关键词:...
Fluorine in pharmaceutical industry:fluorine-containing drugs introduced to the market in the last decade (2001-2011). WANG J,SANCHEZ-ROSELLO M,ACENA J ... Jiang WangMaría Sanchez-RoselloJoseLuis AcenaCarlos del PozoAlexander E. SorochinskySantos FusteroVadim A. SoloshonokHong Liu - 《Chemical...
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The demand for anti-tumor drugs is still very urgent.Some studies have shown that fluorine-containing complexes have good biological activity.In this paper... C Niu - 《Shandong Chemical Industry》 被引量: 0发表: 2019年 FLUORINE-CONTAINING POLYETHERS. BIMONTHLY REPORT NO. 4 FOR OCTOBER 12, ...
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To meet the growing demands for the development of new molecular entities for discovering new drugs and materials, organic chemists have started looking fo... Tushar K. Chakraborty, Sarva Jayaprakash, Subhash Ghosh - 《Combinatorial Chemistry & High Throughput Screening》 被引量: 102发表: 2002年 ...
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However, progress in the field of carbohydrate-based drugs has been limited. This can be attributed to their high polarity, resulting in low binding affinities, as well as their poor pharmacokinetic properties, such as short residence time and rapid renal excretion. In recent years, fluorine has...