The present invention relates to the use of peptides that are capable of binding to, and modulating the activity of NCAM. The peptides are peptide fragments of FGFRs. They are derived from two distinct binding sites for binding of the immunoglobulin-like module 2 of FGFR to NCAM F3 modules...
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From this reservoir, FGFs may act directly on target cells, or they can be released through digestion of the ECM or the activity of a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor ...
The fibroblast growth factor receptor (FGFR) gene is located onchromosome 8at position 12 and encodes for atyrosine kinasereceptor belonging to the FGFR family. The FGFR family includes four receptor tyrosine kinases (FGFRs 1–4). When ligand-receptor binding occurs, FGFR dimerizes and phosphorylate...
16 reagents referenced in Fibroblast growth factor receptor 2 homodimerization rapidly reduces transcription of the pluripotency gene Nanog without dissociation of activating transcription factors.
Multivalent ligand-receptor binding interactions in the fibroblast growth factor system produce a cooperative growth factor and heparin mechanism for recep... “Multivalent Ligand-Receptor Binding Interactions in the Fibroblast Growth Factor System Produce a Cooperative Growth Factor and Heparin Mechanism for...
Alternative splicing in the extracellular domain is a characteristic feature of members of the fibroblast growth factor receptor (FGFR) family. This splicing event generates receptor variants, which differ in their ligand binding specificities. A poorly characterized splice variant is FGFR1 – IIIb, rece...
Analyzes the fibroblast growth factors (FGF) signaling in osteoblasts. Role of FGF in cell death induction and differentiation of osteoblasts; Impact of th... Mansukhani,Alka,Bellosta,... - 《Journal of Cell Biology》 被引量: 366发表: 2000年 Fibroblast growth factor receptor is required for in...