基于上述实例,在体外研究中,技术人员为了模拟高甘油三酯和游离脂肪酸所致的脂毒性,通常需要添加高浓度的硬脂酸(Stearic acid),软脂酸(软脂酸,Palmitic acid),和/或油酸(Oleic acid),这是因为上述三种脂肪酸是存在于动物、植物及微生物中最常见的饱和/不饱和游离脂肪酸。正常情况下,人体血液中上述三种脂肪酸的浓度维...
Ni and Meunier carried out the esterification of palmitic acid mixed with sunflower oil in the presence of SO4/ZrO2 at 333 K, and showed that the conversion ratio into FAME was above 60% at 5 h of the reaction time [15]. However, reuse of sulfated zirconia brought about its deactivation...
In addition, the omega-6 fatty acids linoleic acid and γ-linoleic acid also dose-dependently increase [Ca2+]i, but the mono-unsaturated fatty acid oleic acid and saturated fatty acids such as stearic acid and palmitic acid had no effect. In HCT116 and HT-29 cells, the αLA-induced [...
半月苔酸(lumularic acid),对-香豆酸(p-coumaric acid),对-羟基苯甲酸(p-hydroxybenzoic acid)以及硬脂酸(stearic acid),棕榈酸,油酸(oleic acid),亚油酸(linoleic acid),肉豆蔻酸(myristic acid),十二(烷)酸(pentadecan
[0083]主要采用INS‑1细胞体外模拟高脂对β细胞的毒性作用,建立高脂损伤模型,即分别用含有不同浓度棕榈酸(Palmitic acid,PA)的培养基培养INS‑1细胞24h后,通过MTT法考察不同浓度的棕榈酸对INS‑1细胞的毒性。 [0084](3)血竭素及其衍生物对高糖损伤胰岛β细胞的保护作用 [0085]将不同浓度的血竭素及其衍生物...