基于上述实例,在体外研究中,技术人员为了模拟高甘油三酯和游离脂肪酸所致的脂毒性,通常需要添加高浓度的硬脂酸(Stearic acid),软脂酸(软脂酸,Palmitic acid),和/或油酸(Oleic acid),这是因为上述三种脂肪酸是存在于动物、植物及微生物中最常见的饱和/不饱和游离脂肪酸。正常情况下,人体血液中上述三种脂肪酸的浓度维持在生理范
palmitic acidThe uptake, release, and oxidation of individual free fatty acids (FFA) in the human forearm were studied during a 60-min exercise period. Muscular uptake of FFA rose with the arterial concentration. The muscle showed a slight preference for linoleic and oleic acid compared to ...
In addition, the omega-6 fatty acids linoleic acid and γ-linoleic acid also dose-dependently increase [Ca2+]i, but the mono-unsaturated fatty acid oleic acid and saturated fatty acids such as stearic acid and palmitic acid had no effect. In HCT116 and HT-29 cells, the αLA-induced [...
Figure 1.High concentrations of palmitic acid (PA) inhibit the expression oftranscription factor 2(TCF2) in β-cells. Viability of INS-1 β-cells was analyzed after treatment with a concentration gradient concentration of PA for 48 h, then 0.5 mg/mL 3-(4,5-dimethyl-2-thiazolyl)-2,5-dip...
小.qC16-0-LG3-1 具有最大的表型贡献率, 可解释 表 2 棉籽 4 个品质性状的相关性分析 Table 2 Correlation analysis among four quality traits of cottonseeds 性状 Trait 油分 Oil content 棕榈酸 Palmitic acid content 油分 Oil content 1.00000 棕榈酸 Palmitic acid content 0.45145** 1.00000 油酸 ...
4-甲基-1,2,3-三噻烷(4-methyl-1,2,3-trithiane),二甲基四硫化物(dimethyl tetrasulfide),二丙基三硫化物(dipropyl trisulfide),3,5-二甲基-1,2,4-三噻烷(3,5-dimethyl-1,2,4-trithiane),5-甲基 -1,2,3,4-四噻烷...
[0083]主要采用INS‑1细胞体外模拟高脂对β细胞的毒性作用,建立高脂损伤模型,即分别用含有不同浓度棕榈酸(Palmitic acid,PA)的培养基培养INS‑1细胞24h后,通过MTT法考察不同浓度的棕榈酸对INS‑1细胞的毒性。 [0084](3)血竭素及其衍生物对高糖损伤胰岛β细胞的保护作用 [0085]将不同浓度的血竭素及其衍生物...
(T2D; haemoglobin A1c 9%–13% on ≥2 oral antihyperglycaemic agents (OADs) ± glucagon‐like peptide‐1 receptor agonist (GLP‐1 RA) therapy) increased time in range (TIR; primary endpoint) from 26.4% at baseline to 52.7% at Week 16. This exploratory analysis examined the impact ...