该基因编码免疫球蛋白受体超家族的一个成员,是聚集在1号染色体长臂上的几种Fc受体样糖蛋白之一该编码蛋白具有四个细胞外c2型免疫球蛋白结构域、一个跨膜结构域和一个包含三个免疫受体酪氨酸抑制基序的细胞质结构域。这种蛋白可能在上皮内记忆b细胞的功能中起作用。编码该基因的染色体区域异常与非霍奇金淋巴瘤和多发...
thereby acting as an inhibitory receptor in B cells. CD307d is homologous to FcgammaRI and specifically binds IgA. To date, CD307d is the only known inhibitory receptor for IgA. Expression of CD307d is increased on memory B cells from patients with chronic infections such as...
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a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs.This protein may play a role in the function of memory B-cells in the epithelia.Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and ...
Expression of CD307d is increased on memory B cells from patients with chronic infections such as HIV, suggesting that enhanced expression of inhibitory receptors, such as CD307d, may contribute to the inefficiency of antibody responses against HIV.Applications Reported: This 413D12 antibody ha...