(FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes/macrophages, natural killer...
It is a low affinity, transmembrane receptor that is mainly expressed in monocytes, natural killer cells, and macrophages. It has been implicated in various inflammatory conditions, and recently a polymorphism (rs396991) in this gene has been shown to influence response to rituximab (anti-CD20) ...
(NK) cells, monocytes, and macrophages. The FcγRIIIA receptor is involved in phagocytosis, secretion of enzymes, inflammatory mediators, antibody-dependent cellular cytotoxicity (ADCC), mast cell degranulation, and clearance of immune complexes. FcγRIIIA has an immunoreceptor tyrosine-based ...
(FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes/macrophages, natural killer (NK) ...
Rituximab (RTX) is an anti-CD20 antibody with a native IgG1 Fc, which crosslinks Fc receptors (Fc纬Rs) expressed on immune effector cells. NK cells, which express Fc纬RIIIa, are believed to play an important role with less well-characterised contribution from monocytes/macrophages and ...
Compared to Caucasians, Black individuals had significantly lower proportions of Fc gamma RIIIa-positive natural killer (NK) cells (95.2% vs. 96.9%) and CD8(+) T lymphocytes (9.6% vs. 11.7%), whereas the opposite was true for monocytes (24.2% vs. 16.3%). However, Black individuals had...