False Discovery RateMultiple Hypothesis TestingProteoformTDCD_FDR_CALCULATORTop-Down ProteomicsAuthor contributions: R.D.L., R.T.F., B.P.E., D.P.S., P.M.T., and N.L.K. designed research; R.D.L., R.T.F., B.P.E., J.B.G., and D.P.S. analyzed data; R.D.L., R.T...
Here we present a fully automated open-source workflow for high-throughput metabolomics that combines data-dependent and data-independent acquisition for library generation, analysis, and statistical validation, with rigorous control of the false-discovery rate while matching manual analysis regarding ...
0 1 Power False Discovery Rate Proportion of tests that follows the null distribution Implications ? Justification of traditional choice ?=0.05 – False positive rate ~ ?, when ?0 ~ ? and 1-??1 Implications ? Justification of traditional choice ?=0.05 – False positive rate ~ ?, when ?0...