Durvalumab (IMFINZI), a fully human monoclonal antibody against programmed cell death-ligand 1 (PD-L1), is approved for use in combination with etoposide and either carboplatin or cisplatin for the first-line treatment of patients with extensive-stage small cell lung cancer (ES-SCLC). In the p...
We explored potential predictive biomarkers of immunotherapy response in patients with extensive-stage small-cell lung cancer (ES-SCLC) treated with durvalumab (D) + tremelimumab (T) + etoposide-platinum (EP), D + EP, or EP in the randomized phase 3 CASPIAN trial. Methods 805 ...
Patient selection Patients were enrolled in this study if they met the following criteria: (1) a histological or cytological diagnosis of SCLC; (2) no prior treatment; (3) measurable disease; (4) ED, defined as having distant metastasis or contralateral hilar lymph node metastasis; (5) perfor...
Conclusions and Relevance Among patients with previously untreated extensive-stage SCLC, serplulimab plus chemotherapy significantly improved overall survival compared with chemotherapy alone, supporting the use of serplulimab plus chemotherapy as the first-line treatment for this patient population. Trial ...
3, Dong Ding1, Shuosha Li1, Mengting Liao4, Yin Shi5 and Jin Huang1,6* Abstract Background: The clinical trial of Keynote-604 showed that pembrolizumab plus chemotherapy could generate clini- cal benefits for extensive-stage small-cell lung cancer (ES-SCLC)...